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Anti-S100B Antibody
| 产品编号： | 4114014 |
| 规格： | from rabbit, purified by affinity chromatography |
| 包装规格： | 100 μG |
| 产品类别： | 进口试剂 |
| 品牌： | Sigma-Aldrich |
| 优惠价： | 立即咨询 |
产品别名
Anti-S100B Antibody
Protein S100-B, S-100 protein beta chain, S-100 protein subunit beta, S100 calcium-binding protein B
基本信息
| eCl@ss | 32160702 |
| NACRES | NA.41 |
| General description【一般描述】 | S-100 protein is a member of the EF-hand calcium-binding protein superfamily that is widely distributed and conserved in the central nervous system of vertebrates. The protein exists in both heterodimeric and homodimeric forms. The two subunits of S-100 protein are the products of separate genes that are differentially expressed by various cells. The beta subunit is present in all S-100 positive cells and tumors. In contrast, the alpha subunit is detectable only in heart, skeletal muscle and brain. In addition to its calcium binding properties, S-100 protein has a high-affinity binding site for zinc and is involved in the regulation of protein phosphorylation in the brain. The protein apparently plays a role in cell differentiation and growth, cytoskeletal structure and function, and has been implicated in neuropathological diseases. |
| Immunogen【免疫原】 | Epitope: Near N-Terminus KLH-conjugated linear peptide corresponding to human S100B near the N-Terminus. |
| Application【应用】 | Immunohistochemistry Analysis: A 1:2,000 dilution from a representative lot detected S100B in human thalamus and human cerebellum sections. Research Category Neuroscience Detect S100 using this rabbit polyclonal antibody, Anti-S100B Antibody validated for use in western blotting & IHC (Paraffin). Research Sub Category Developmental Signaling |
| Quality【质量】 | Evaluated by Western Blotting in A375 cell lysate. Western Blotting Analysis: 0.1 µg/mL of this antibody detected S100B in 10 µg of A375 cell lysate. |
| Linkage【联系】 | Replaces: 04-1054 |
| Physical form【外形】 | Purified rabbit polyclonal in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide. Affinity purified |
| Other Notes【其他说明】 | Concentration: Please refer to the Certificate of Analysis for the lot-specific concentration. |
产品性质
| Quality Level【质量水平】 | 300 100 |
| biological source【生物来源】 | rabbit |
| antibody form【抗体形式】 | affinity isolated antibody |
| antibody product type | primary antibodies |
| clone【克隆】 | polyclonal |
| purified by【纯化方式】 | affinity chromatography |
| species reactivity | human |
| species reactivity (predicted by homology) | bovine (based on 100% sequence homology), mouse (based on 100% sequence homology), rhesus macaque (based on 100% sequence homology), rat (based on 100% sequence homology) |
| technique(s) | immunohistochemistry: suitable (paraffin) western blot: suitable |
| NCBI accession no.【NCBI登记号】 | NP_006263 |
| UniProt accession no.【UniProt登记号】 | P04271 |
| shipped in【运输】 | wet ice |
产品说明
| Target description【目标描述】 | ~10 kDa observed |
| Storage and Stability【储存及稳定性】 | Stable for 1 year at 2-8°C from date of receipt. |
| Disclaimer【免责声明】 | Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. |
安全信息
| Storage Class Code【储存分类代码】 | 13 - Non Combustible Solids |
| WGK | WGK 1 |
