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Anti-Splicing Factor SC-35 antibody, Mouse monoclonal
| 产品编号： | 4114701 |
| 规格： | clone SC-35, purified from hybridoma cell culture |
| 包装规格： | 100 μL |
| 产品类别： | 进口试剂 |
| 品牌： | Sigma-Aldrich |
| 优惠价： | 立即咨询 |
产品别名
Anti-Splicing Factor SC-35 antibody, Mouse monoclonal
Anti-serine/arginine-rich splicing factor 2 (SRSF2)
Anti-Splicing component 35 kDa (SC35)
Anti-SFRS2A
Anti-SRp30b
Anti-SFRS2
Anti-PR264
产品性质
| Quality Level【质量水平】 | 200 |
| biological source【生物来源】 | mouse |
| antibody form【抗体形式】 | purified from hybridoma cell culture |
| antibody product type | primary antibodies |
| clone【克隆】 | SC-35, monoclonal |
| form【形式】 | buffered aqueous solution |
| mol wt【分子量】 | ~35 kDa |
| species reactivity | mouse, human, frog, rat, quail, hamster, porcine |
| concentration【浓度】 | ~1.0 mg/mL |
| technique(s) | ELISA: suitable dot blot: suitable immunoblotting: suitable immunofluorescence: 0.125-0.25 μg/mL using HeLa cells immunohistochemistry: suitable immunoprecipitation (IP): suitable |
| UniProt accession no.【UniProt登记号】 | Q01130 |
| shipped in【运输】 | dry ice |
| storage temp.【储存温度】 | −20℃ |
基本信息
| General description【一般描述】 | Anti-Splicing Factor SC-35 antibody, Mouse monoclonal (mouse IgG1 isotype) is derived from the SC-35 hybridoma produced by the fusion of mouse myeloma cells and splenocytes from a RBF-DHJ mouse immunized with partially purified spliceosomes prepared from HeLa cells. Splicing Factor SC-35, also known as serine/arginine rich splicing factor 2 (SRSF2) belongs to the family of of serine/arginine-rich (SR) proteins. |
| Immunogen【免疫原】 | partially purified spliceosomes prepared from HeLa cells |
| Application【应用】 | Anti-Splicing Factor SC-35 antibody has been used in
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| Biochem/physiol Actions【生化/生理作用】 | Splicing Factor SC-35 are critical regulators of constitutive and alternative pre-mRNA splicing. It also controls cellular apoptosis in response to genotoxic stress. Serine/arginine protein kinase 1 (SRPK1) specifically phosphorylates SC-35, resulting in p53 suppression and cyclin D1 upregulation. Elevated levels of SC-35 correlate with aggressive phenotype in several cancer types including lung squamous cell carcinoma and lung adenocarcinoma. SC-35 has oncogenic function in tumor progression of human papilloma virus (HPV)-infected cells. |
| Physical form【外形】 | Solution in 0.01 M phosphate buffered saline, pH 7.4, containing 15 mM sodium azide. |
产品说明
| Disclaimer【免责声明】 | Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. |
安全信息
| Storage Class Code【储存分类代码】 | 12 - Non Combustible Liquids |
| WGK | WGK 1 |
