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Anti-TFE3 antibody produced in rabbit
| 产品编号： | 4115153 |
| 规格： | affinity isolated antibody, buffered aqueous solution |
| 包装规格： | 25 μL |
| 产品类别： | 进口试剂 |
| 品牌： | Sigma-Aldrich |
| 优惠价： | 立即咨询 |
产品别名
Anti-TFE3 antibody produced in rabbit
Anti-Class E basic helix-loop-helix protein 33
Anti-BHLHE33
Anti-Transcription factor E3
基本信息
| NACRES | NA.41 |
| General description【一般描述】 | Transcription factor E3 (TFE3), also known as Class E basic helix-loop-helix protein 33 (bHLHe33), is a transcriptional activator that mediates the enhancer-promoter interactions. TFE3 belongs to the MiT family of helix-loop-helix leucine zipper transcription factors, it is ubiquitously expressed and can directly associate with DNA as either homodimer or heterodimer formed with two other MiT family members, TFEB or TFEC. TFE3 serves an important role in cell growth, cell proliferation, in cellular adaptation to starvation and cellular response to ER stress. Under nutrient-rich conditions TFE3 is located in the cytoplasm, under starvation conditions or treatment with ER stressors, TFE3 rapidly translocated to nuclear, there it mediates cellular adaptation to stress by simultaneously promoting lysosomal biogenesis, autophagy induction, as well as expression of critical mitochondrial and metabolic regulators. TFE3 has been shown to participate in the transcriptional regulation of the innate immune response. in addition, it was demonstrated that pathogen infections promote TFE3 nuclear translocation, thus inducing the expression of several cytokines and chemokines. Anti-TFE3 antibody specifically recognizes TFE3 from human and mouse origin. |
| Immunogen【免疫原】 | Synthetic peptide corresponding to the human TFE3 |
| Application【应用】 | The antibody may be used in various immunochemical techniques including Immunoblotting (∼60 kDa) and Immunofluorescence. Detection of the TFE3 band by Immunoblotting is specifically inhibited by the immunizing peptide. |
| Physical form【外形】 | Supplied as a solution in 0.01 M phosphate buffered saline pH 7.4, containing 15 mM sodium azide as a preservative. |
| Other Notes【其他说明】 | This product is for R&D use only, not for drug, household, or other uses. |
产品性质
| biological source【生物来源】 | rabbit |
| antibody form【抗体形式】 | affinity isolated antibody |
| antibody product type | primary antibodies |
| clone【克隆】 | polyclonal |
| form【形式】 | buffered aqueous solution |
| mol wt【分子量】 | ~60 kDa |
| species reactivity | human, mouse |
| packaging【包装】 | antibody small pack of 25 μL |
| concentration【浓度】 | ~1.0 mg/mL |
| technique(s) | immunoblotting: 4-8 μg/mL using human HeLa cells extract immunofluorescence: 2.5-5 μg/mL using mouse embryo fibroblast NIH-3T3 cells |
| UniProt accession no.【UniProt登记号】 | P19532 |
| shipped in【运输】 | dry ice |
| storage temp.【储存温度】 | −20℃ |
| Gene Information | human ... TFE3(7030) |
安全信息
| Storage Class Code【储存分类代码】 | 12 - Non Combustible Liquids |
| WGK | WGK 3 |
