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Anti-Thorase Antibody, clone 9G7.1
产品别名
Anti-Thorase Antibody, clone 9G7.1
ATPase family AAA domain-containing protein 1, Thorase
基本信息
| eCl@ss | 32160702 |
| NACRES | NA.41 |
| General description【一般描述】 | Thorase is an ATPase that plays a critical role in regulating the surface expression of AMPA receptors (AMPAR). Thorase thus helps mediate synaptic plasticity and learning and memory. Thorase expression is required for NMDA-stimulated AMPAR internalization and for the inhibition of GRIA1 and GRIA2 recycling back to the plasma membrane as both of these require ATP processing by Thorase. Thorase is vital for keeping in balance the molecular construction-deconstruction cycle that is required for memory formation. Thorase is one of many AAA+ ATPases that drive the assembly of proteins needed to form specialized receptors at the surfaces of synapses. These receptors are stimulated by neighboring neurons, setting up the signaling and answering connections vital to brain function. Thorase regulates the all-important complementary process of receptor disassembly at synapses, which ultimately tamps down signaling. Thorase is a postsynaptic localized protein, and also is associated with the peroxisome and cell junctions and synapses. Thorase is expressed in the brain and testis primarily. |
| Immunogen【免疫原】 | GST-tagged recombinant protein corresponding to human Thorase. |
| Application【应用】 | This Anti-Thorase Antibody, clone 9G7.1 is validated for use in Western Blotting for the detection of Thorase. Western Blotting Analysis: 1.0 µg/mL from a representative lot detected Thorase in 10 µg of human brain tissue lysate. |
| Quality【质量】 | Evaluated by Western Blotting in human lymph node tissue lysate. Western Blotting Analysis: 1.0 µg/mL of this antibody detected Thorase in 10 µg of human lymph node tissue lysate. |
| Physical form【外形】 | Protein G Purified Format: Purified |
| Other Notes【其他说明】 | Concentration: Please refer to lot specific datasheet. |
产品性质
| Quality Level【质量水平】 | 100 |
| biological source【生物来源】 | mouse |
| antibody form【抗体形式】 | purified immunoglobulin |
| antibody product type | primary antibodies |
| clone【克隆】 | 9G7.1, monoclonal |
| species reactivity | human |
| species reactivity (predicted by homology) | mouse (based on 100% sequence homology) |
| technique(s) | western blot: suitable |
| isotype【同位素/亚型】 | IgG2bκ |
| NCBI accession no.【NCBI登记号】 | NP_116199 |
| UniProt accession no.【UniProt登记号】 | Q8NBU5 |
| shipped in【运输】 | wet ice |
| Gene Information | human ... ATAD1(84896) |
产品说明
| Target description【目标描述】 | ~41 kDa observed |
| 【免责声明】 | Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. |
安全信息
| Storage Class Code【储存分类代码】 | 12 - Non Combustible Liquids |
| WGK | WGK 1 |
