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Anti-TM4SF4 antibody, Mouse monoclonal
| 产品编号： | 4115387 |
| 规格： | clone TM4SF-11, hybridoma cell culture supernatant |
| 包装规格： | 100 μL |
| 产品类别： | 进口试剂 |
| 品牌： | Sigma-Aldrich |
| 优惠价： | 立即咨询 |
产品别名
Anti-TM4SF4 antibody, Mouse monoclonal
Anti-ILTMP
Anti-il-TMP transmembrane 4 L six family member 4
基本信息
| NACRES | NA.41 |
| General description【一般描述】 | Anti-TM4SF4 antibody, Mouse monoclonal (mouse IgM isotype) is derived from the TM4SF-11 hybridoma, produced by the fusion of mouse myeloma cells and splenocytes from BALB/c mouse immunized with synthetic peptide from the internal region of human TM4SF4, conjugated to KLH. TM4SF4 (Transmembrane 4 L6 Family member 4) also known as ILTMP (intestine and liver tetraspan membrane protein) is a member of the transmembrane 4 superfamily (or tetraspanin family). It is a cell surface glycoprotein containing four transmembrane domains. |
| Immunogen【免疫原】 | synthetic peptide from the internal region of human TM4SF4 |
| Application【应用】 | Anti-TM4SF4 antibody has been used in immunoblotting. |
| Biochem/physiol Actions【生化/生理作用】 | TM4SF4 (Transmembrane 4 L6 Family member 4) can intervene density-dependent cell proliferation. TM4SF4 levels increases in non-dividing epithelial cells during their differentiation and migration of intestinal crypts. TM4SF4 levels are upregulated in 80% of hepatocellular carcinoma (HCC) tissues and in stomach adenocarcinoma cells. Reduction of TM4SF4 expression in HCC cell lines by stably transfecting TM4SF4 antisense plasmid caused significant inhibition of cell proliferation. |
| Physical form【外形】 | The product is supplied as a culture supernatant solution containing 15 mM sodium azide as a preservative. The product contains bovine serum albumin and a human-derived protein. |
产品性质
| Quality Level【质量水平】 | 200 |
| antibody form【抗体形式】 | culture supernatant |
| antibody product type | primary antibodies |
| clone【克隆】 | TM4SF-11, monoclonal |
| form【形式】 | buffered aqueous solution |
| mol wt【分子量】 | antigen ~27 kDa |
| species reactivity | bovine, human, mouse, canine, monkey, rat |
| technique(s) | immunoblotting: 1:4,000-1:8,000 using whole extract of HCT-116 cells |
| isotype【同位素/亚型】 | IgM |
| UniProt accession no.【UniProt登记号】 | P48230 |
| shipped in【运输】 | dry ice |
| storage temp.【储存温度】 | −20℃ |
| Gene Information | human ... TM4SF4(7104) mouse ... Tm4sf4(229302) rat ... Tm4sf4(116467) |
产品说明
| Disclaimer【免责声明】 | Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. |
安全信息
| Storage Class Code【储存分类代码】 | 12 - Non Combustible Liquids |
| WGK | WGK 1 |
