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Anti-trimethyl Histone H3 (Lys36) Antibody
| 产品编号： | 4115555 |
| 规格： | from rabbit, purified by affinity chromatography |
| 包装规格： | 100 μL |
| 产品类别： | 进口试剂 |
| 品牌： | Sigma-Aldrich |
| 优惠价： | 立即咨询 |
产品别名
Anti-trimethyl Histone H3 (Lys36) Antibody
Histone H3.1, Histone H3/a, Histone H3/b, Histone H3/c, Histone H3/d, Histone H3/f, Histone H3/h, Histone H3/I, Histone H3/j, Histone H3/k, Histone H3/l, H3k36me3
基本信息
| eCl@ss | 32160702 |
| NACRES | NA.41 |
| General description【一般描述】 | Histones are highly conserved proteins that serve as the structural scaffold for the organization of nuclear DNA into chromatin. The four core histones, H2A, H2B, H3, and H4, assemble into an octamer (2 molecules of each). Subsequently, 146 base pairs of DNA are wrapped around the octamer, forming a nucleosome, the basic subunit of chromatin. Histones are modified post-translationally by the actions of enzymes in both the nucleus and cytoplasm. These modifications regulate DNA transcription, repair, recombination, and replication. The most commonly studied modifications are acetylation, phosphorylation, methylation, and ubiquitination. These modifications can alter local chromatin architecture, or recruit trans-acting factors that recognize specific histone modifications (the "histone code" hypothesis). The modifications occur predominantly on the N-terminal and C-terminal tails that extend beyond the nucleosome core particle. Methylation of histone H3 on Lys36 (H3K36me2/3) is tightly associated with actively transcribed genes, and this modification is found primarily within the coding region, suggesting H3K36 methylation is necessary for efficient RNA polymerase II elongation and processivity. |
| Application【应用】 | Use Anti-trimethyl Histone H3 (Lys36) Antibody (Rabbit Polyclonal Antibody) validated in WB, DB, ICC, ChIP to detect trimethyl Histone H3 (Lys36) also known as H3K36me3, Histone H3 (tri methyl K36). |
| Quality【质量】 | Evaluated by Western Blot in Histone H3 recombinant proteins. Western Blot Analysis: A 1:2,000 dilution of this antibody detected Histone H3 on 10 µg of Histone H3 recombinant proteins. |
| Other Notes【其他说明】 | Affinity purified |
产品性质
| biological source【生物来源】 | rabbit |
| Quality Level【质量水平】 | 100 |
| antibody form【抗体形式】 | affinity isolated antibody |
| antibody product type | primary antibodies |
| clone【克隆】 | polyclonal |
| purified by【纯化方式】 | affinity chromatography |
| species reactivity | mouse, human |
| technique(s) | ChIP: suitable dot blot: suitable immunocytochemistry: suitable western blot: suitable |
| NCBI accession no.【NCBI登记号】 | NP_003520 |
| UniProt accession no.【UniProt登记号】 | P68431 |
| shipped in【运输】 | wet ice |
| Gene Information | human ... HIST1H3F(8968) |
产品说明
| Target description【目标描述】 | ~17 kDa observed |
| 【免责声明】 | Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. |
安全信息
| Storage Class Code【储存分类代码】 | 12 - Non Combustible Liquids |
| WGK | WGK 1 |
