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Anti-TTC8 Antibody
| 产品编号： | 4115668 |
| 规格： | from rabbit, purified by affinity chromatography |
| 包装规格： | 100 μG |
| 产品类别： | 进口试剂 |
| 品牌： | Sigma-Aldrich |
| 优惠价： | 立即咨询 |
产品别名
Anti-TTC8 Antibody
Tetratricopeptide repeat protein 8, TPR repeat protein 8, Bardet-Biedl syndrome 8 protein, TTC8
基本信息
| eCl@ss | 32160702 |
| NACRES | NA.41 |
| General description【一般描述】 | Also known as tetratricopeptide repeat protein 8, TTC8 is a BBSome complex that is required for ciliogenesis. It is known to associate with the Rab8 GDP/GTP exchange factor, which is localized in the basal body. Rab8(GTP) is produced and enters the primary cilium, where it promotes ciliary membrane biogenesis. Mutations in TTC8 have been identified in Bardet-Biedl syndrome (BBS), a genetic disorder which is characterized with obesity, retinal degeneration, and nephropathy. |
| Specificity【特异性】 | This antibody recognizes the TPR1 domain of TTC8. Other homologies: Rat (53% sequence homology). |
| Immunogen【免疫原】 | KLH-conjugated linear peptide corresponding to the TPR1 domain of human TTC8. Epitope: TPR1 domain |
| Application【应用】 | Anti-TTC8 detects levels of TTC8 proteins & has been published & validated for use in WB & IHC. Immunohistochemistry Analysis: A 1:2,000 dilution from a representative lot detected TTC8 in human prostate cancer and mouse eye tissues. Research Category Neuroscience Research Sub Category Cytoskeleton |
| Quality【质量】 | Evaluated by Western Blot in ARPE19 tissue lysate. Western Blot Analysis: 1 µg/mL of this antibody detected TTC8 in 10 µg of ARPE19 tissue lysate. |
| Physical form【外形】 | Purified rabbit polyclonal in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide. Affinity purified |
| Analysis Note【分析说明】 | Control ARPE19 tissue lysate |
| Other Notes【其他说明】 | Concentration: Please refer to the Certificate of Analysis for the lot-specific concentration. |
产品性质
| Quality Level【质量水平】 | 300 |
| biological source【生物来源】 | rabbit |
| antibody form【抗体形式】 | affinity isolated antibody |
| antibody product type | primary antibodies |
| clone【克隆】 | polyclonal |
| purified by【纯化方式】 | affinity chromatography |
| species reactivity | horse, human, mouse |
| species reactivity (predicted by homology) | equine (based on 100% sequence homology), primate (based on 100% sequence homology), porcine (based on 100% sequence homology) |
| technique(s) | immunohistochemistry: suitable western blot: suitable |
| NCBI accession no.【NCBI登记号】 | NP_653197 |
| UniProt accession no.【UniProt登记号】 | Q8TAM2 |
| shipped in【运输】 | wet ice |
产品说明
| Target description【目标描述】 | ~61 kDa observed. Uncharacterized bands at ~270 kDa, ~160 kDa, and ~38 kDa may be observed in some cell lysates. |
| Storage and Stability【储存及稳定性】 | Stable for 1 year at 2-8°C from date of receipt. |
| Disclaimer【免责声明】 | Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. |
安全信息
| Storage Class Code【储存分类代码】 | 10 - Combustible liquids |
