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Anti-USP7S Antibody
| 产品编号： | 4115890 |
| 规格： | from rabbit, purified by affinity chromatography |
| 包装规格： | 100 μL |
| 产品类别： | 进口试剂 |
| 品牌： | Sigma-Aldrich |
| 优惠价： | 立即咨询 |
产品别名
Anti-USP7S Antibody
Ubiquitin carboxyl-terminal hydrolase 7, Deubiquitinating enzyme 7, Herpesvirus-associated ubiquitin-specific protease, Ubiquitin thioesterase 7, Ubiquitin-specific-processing protease 7
基本信息
| eCl@ss | 32160702 |
| NACRES | NA.41 |
| General description【一般描述】 | The protein named Ubiquitin carboxyl-terminal hydrolase 7, or Deubiquitinating enzyme 7, Herpesvirus-associated ubiquitin-specific protease, Ubiquitin thioesterase 7, or Ubiquitin-specific-processing protease 7 and encoded by the human gene USP7/HAUSP is a ubiquitin specific hydrolase that deubiquitinates several key transcription factors and thus modulates their activity. Among the important factors are FOXO4, p53, MDM2, ERCC6, DNMT1, UHRF1, PTEN, and DAXX. Thus USP7S is involved in cell proliferation and gene expression regulation and the regulation of the stress response pathways. Interestingly recent research has linked USP7S with regulating transcription-coupled nucleotide excision repair (TC-NER) and the being important in the disease of UV-sensitive syndrome (UVSS) too. USP7S is widely expressed and up regulated in many cancers including prostate cancer. |
| Immunogen【免疫原】 | Epitope: N-terminus KLH-conjugated linear peptide corresponding to a region near the N-terminus of human USP7S. |
| Application【应用】 | Anti-USP7S Antibody detects level of USP7S & has been published & validated for use in USP7S. Western Blotting Analysis: A 1:5,000 dilution of this antibody detected USP7S in HeLa whole cell extract (Dr. Grigory Dianov, University of Oxford, United Kingdom.) Research Sub Category Apoptosis - Additional Research Category Apoptosis & Cancer |
| Quality【质量】 | Evaluated by Western Blotting in HeLa cell lysate. Western Blotting Analysis: A 1:1,000 dilution of this antibody detected USP7S in 10 µg in HeLa cell lysate. |
| Physical form【外形】 | Purified rabbit polyclonal in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide. Affinity purified |
产品性质
| biological source【生物来源】 | rabbit |
| Quality Level【质量水平】 | 100 |
| antibody form【抗体形式】 | affinity isolated antibody |
| antibody product type | primary antibodies |
| clone【克隆】 | polyclonal |
| purified by【纯化方式】 | affinity chromatography |
| species reactivity | human |
| species reactivity (predicted by homology) | mouse (based on 100% sequence homology), Xenopus (based on 100% sequence homology), rat (based on 100% sequence homology), porcine (based on 100% sequence homology) |
| technique(s) | western blot: suitable |
| NCBI accession no.【NCBI登记号】 | NP_003461 |
| UniProt accession no.【UniProt登记号】 | Q93009 |
| shipped in【运输】 | wet ice |
| Gene Information | human ... USP7(7874) |
产品说明
| Target description【目标描述】 | ~140 kDa observed |
| Storage and Stability【储存及稳定性】 | Stable for 1 year at 2-8°C from date of receipt. |
| Disclaimer【免责声明】 | Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. |
安全信息
| Storage Class Code【储存分类代码】 | 12 - Non Combustible Liquids |
| WGK | WGK 1 |
