Anti-VCAM-1 (CD106) Antibody, clone 6C7.1

32160702

NA.41

Vascular cell adhesion protein 1 (VCAM-1) is a cell surface adhesion molecule belonging to the immunoglobulin cell-cell adhesion receptor family and is comprised of seven Ig-like C2-type domains. VCAM-1 is a crucial component in cell-cell recognition and seems to be involved in cellular adhesion between endothelial cells and leukocytes. It has a regulatory role for both signal transduction and adhesion through its interaction with leukocyte beta-1 integrin VLA4, an interaction that is potentially involved in immune and inflammatory emigration responses of leukocytes. Studies have shown upregulation of VCAM-1 to be critical in responding to inflammatory diseases such as atherosclerosis. VCAM-1 is primarily expressed in endothelial cells and is expressed as two known isoforms found within the cell membrane. Isoform 1 functions as a single-pass type 1 membrane protein, while Isoform 2 acts as a GPI-anchor.

Mouse endothelial cells

Anti-VCAM-1 (CD106) Antibody, clone 6C7.1 is an antibody against VCAM-1 (CD106) for use in FC, IP, IC, IH.
Immunohistochemistry Analysis: A previous lot was used by independent laboratory in IH. (Norman, U., et al. (2008). Journal of Leukocyte Biology. 84:68-76.)

Immunocytochemistry Analysis: A previous lot was used by independent laboratory in IC. (Norman, U., et al. (2008). Journal of Leukocyte Biology. 84:68-76.)

Evaluated by Flow Cytometry in mouse bone marrow cells.

Flow Cytometry Analysis: 10 µg of this antibody detected VCAM-1 on mouse bone marrow cells.

Protein G
Format: Purified

Concentration: Please refer to the Certificate of Analysis for the lot-specific concentration.

100

rat

purified immunoglobulin

primary antibodies

6C7.1, monoclonal

mouse

flow cytometry: suitable
immunocytochemistry: suitable
immunohistochemistry: suitable
immunoprecipitation (IP): suitable

IgG1κ

NP_035823

P29533

dry ice

human ... L1CAM(3897), VCAM1(7412)

81 kDa calculated

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

12 - Non Combustible Liquids

WGK 2