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ApoJ/Clusterin human
产品编号: | 4116458 |
规格: | recombinant, expressed in HEK 293 cells, ≥92% (SDS-PAGE) |
包装规格: | 10 μG |
产品类别: | 进口试剂 |
品牌: | Sigma-Aldrich |
优惠价: | 立即咨询 |
产品别名
ApoJ/Clusterin human
SGP2
TRPM2
SGP-2
Apolipoprotein J
TRPM-2
CLI
KUB1
SP-40
AAG4
MGC24903
CLU
基本信息
NACRES | NA.32 |
General description【一般描述】 | Native Apolipoprotein J (ApoJ), also named Clusterin, is a heavily glycosylated, 75-80 kDa disulfide-linked heterodimeric protein. Despite being cloned since 1989, no genuine function has been attributed to ApoJ so far. The protein has been reportedly implicated in several diverse physiological processes such as sperm maturation, lipid transportation, complement inhibition, tissue remodeling, and membrane recycling, cell-cell and cell-substratum interactions, stabilization of stressed proteins in a folding-competent state and promotion or inhibition of apoptosis. ApoJ gene is differentially regulated by cytokines, growth factors and stress-inducing agents. Clusterin is up- or down regulated on the mRNA or protein level in many pathological and clinically relevant situations including cancer, organ regeneration, infection, Alzheimer disease, retinitis pigmentosa, myocardial infarction, renal tubular damage, autoimmunity and others. |
Physical form【外形】 | Lyophilized from 0.22 μm filtered solution in PBS, pH 7.4. Normally Mannitol or Trehalose is added as protectants before lyophilization. |
Reconstitution【重悬】 | Centrifuge the vial prior to opening. Reconstitute in sterile PBS, pH 7.4 to a concentration of 50 μg/mL. Do not vortex. This solution can be stored at 2-8℃ for up to 1 month. For extended storage, it is recommended to store at -20℃. |
产品性质
biological source【生物来源】 | human |
recombinant【重组】 | expressed in HEK 293 cells |
tag【标签】 | 6-His tagged (C-terminus) |
Assay【测定】 | ≥92% (SDS-PAGE) |
form【形式】 | lyophilized |
mol wt【分子量】 | calculated mol wt 50.9 kDa (Asp23-Glu449, observed mol wt 34-37 kDa by SDS-PAGE (DTT reduced. corresponding to the cleaved |
packaging【包装】 | pkg of 10 μg pkg of 50 μg |
impurities【杂质】 | <1 EU/μg endotoxin (LAL test) |
UniProt accession no.【UniProt登记号】 | P10909 |
shipped in【运输】 | wet ice |
storage temp.【储存温度】 | −20℃ |
Gene Information | human ... CLU(1191) |
安全信息
Storage Class Code【储存分类代码】 | 11 - Combustible Solids |
WGK | WGK 3 |