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BAY-6672 hydrochloride hydrate
产品别名
2640870-12-6
BAY-6672 hydrochloride hydrate
BAY6672 hydrochloride hydrate
BAY 6672 hydrochloride hydrate
hydrochloride hydrate
(+)-(4R)-5-({[6-Bromo-3-methyl-2-(pyrrolidin-1-yl)quinolin-4-yl]carbonyl}amino)-4-(2-chlorophenyl)pentanoic acid
基本信息
| Empirical Formula【经验(实验)分子式】 | C26H27BrClN3O3 · HCl · H2O |
| Molecular weight | 599.34 |
| Biochem/physiol Actions【生化/生理作用】 | BAY-6672 is an orally active, potent and selective prostaglandin F receptor (FP-R, PTGFR) antagonist (IC50 = 11 nM against 3 nM PGF2?-induced calcium flux in hFP-R Chem-1 cells; IC50 = 12/18 nM against 3 μM PGF2α-induced KC/MCP1 production in NIH-3T3) with >420-fold selectivity over human prostaglandin receptors (PG-Rs) EP1-4, DP, CRTH2 and IP. BAY-6672 shows in vivo efficacy in a murine lung fibrosis model (3, 10, 30 mg/kg b.i.d. p.o.). |
产品性质
| Quality Level【质量水平】 | 100 |
| Assay【测定】 | ≥98% (HPLC) |
| form【形式】 | powder |
| color【颜色】 | white to beige |
| solubility【溶解性】 | DMSO: 2 mg/mL, clear |
| storage temp.【储存温度】 | 2-8℃ |
