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依泽替米贝
Ezetimibe
产品价格查看更多规格...
| 产品编号 | 包装单位 | 单价(元) | 国内现货 | 国外库存 | 询价单 |
| 4118582 | 25 MG | 1860 |
产品别名
163222-33-1
依泽替米贝
Ezetimibe
(3R,4S)-1-(4-Fluorophenyl)-3-[(S)-3-(4-fluorophenyl)-3-hydroxypropyl]-4-(4-hydroxyphenyl)azetidin-2-one
(3R,4S)-1-(4-氟苯基)-3-[(S)-3-(4-氟苯基)-3-羟基丙基]-4-(4-羟基苯基)-2-氮杂环丁酮
结构式
基本信息
| Empirical Formula【经验(实验)分子式】 | C24H21F2NO3 |
| Molecular weight | 409.43 |
| MDL number | MFCD00937872 |
| PubChem Substance ID【PubChem化学物质编号】 | 329825513 |
| NACRES | NA.77 |
| Biochem/physiol Actions【生化/生理作用】 | Ezetimibe is a non statin drug that reduces intestinal cholesterol absorption. In addition, it also has an ability to reduce the risk of cardiovascular events in patients who had had an acute coronary syndrome and whose low-density lipoprotein (LDL) cholesterol values were within guideline recommendations. Ezetimibe inhibits intestinal cholesterol absorption by preventing cholesterol uptake by Niemann-Pick C1 Like 1 (NPC1L1) protein that was found critical for the intestinal absorption of cholesterol. Ezetimibe selectvely blocks cholesterol absorption without inhibiting pancreatic lipolytic enzyme activities in the intestinal lumen. |
| Reconstitution【重悬】 | For solubility in aqueous buffer, Ezetimibe should be dissolved in ethanol followed by dilution with the buffer. |
产品性质
| Quality Level【质量水平】 | 200 |
| Assay【测定】 | ≥98% (HPLC) |
| form【形式】 | powder |
| solubility【溶解性】 | DMF: soluble ≥15 mg/mL DMSO: soluble ≥15 mg/mL ethanol: soluble ≥15 mg/mL methanol: soluble ≥15 mg/mL |
| storage temp.【储存温度】 | 2-8℃ |
| SMILES string | FC(C=C1)=CC=C1N([C@H](C2=CC=C(O)C=C2)[C@H]3CC[C@H](O)C4=CC=C(F)C=C4)C3=O |
| InChI | 1S/C24H21F2NO3/c25-17-5-1-15(2-6-17)22(29)14-13-21-23(16-3-11-20(28)12-4-16)27(24(21)30)19-9-7-18(26)8-10-19/h1-12,21-23,28-29H,13-14H2/t21-,22+,23-/m1/s1 |
| InChI key | OLNTVTPDXPETLC-XPWALMASSA-N |
安全信息
| Storage Class Code【储存分类代码】 | 13 - Non Combustible Solids |
| WGK | WGK 3 |
