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Fas Ligand/FasL human

产品编号:4118624
规格:recombinant, expressed in HEK 293 cells, ≥95% (SDS-PAGE)
包装规格:10 μG
产品类别:进口试剂
品牌:Sigma-Aldrich
优惠价:立即咨询
产品价格
产品编号包装单位单价(元)国内现货国外库存询价单
411862410 μG6480
产品别名

Fas Ligand/FasL human

CD95-L

FasLG

ALPS1B

CD95L

FasL

CD178

TNFSF6

APT1LG1

Fas ligand

基本信息
NACRES
NA.32
General description【一般描述】
Fas ligand also known as FasL, CD178, CD95L, or TNFSF6, is a 40 kDa homotrimeric type-II transmembrane protein that belongs to the tumor necrosis factor (TNF) family. The FASL gene was mapped to human chromosome 1q24.3. It spans a length of 8 kb and contains 4 exons. It is found to be expressed on T and NK cells that are activated.
Biochem/physiol Actions【生化/生理作用】
The binding of Fas ligand to its receptor induces apoptosis. Fas ligand/receptor interactions play an important role in the regulation of the immune system and the progression of cancer. Its functions include T-cell homeostasis, cytotoxic T-cell activity, immune privilege, maternal tolerance, tumor counterattack. Defective Fas-mediated apoptosis may lead to oncogenesis as well as drug resistance in existing tumors. Germline mutation of Fas is associated with autoimmune lympho proliferative syndrome (ALPS), a childhood disorder of apoptosis.
Physical form【外形】
Lyophilized from 0.22 μm filtered solution in 50 mM tris, 100 mM glycine, pH 7.0. Normally Mannitol or Trehalose is added as protectants before lyophilization.
Reconstitution【重悬】
Centrifuge the vial prior to opening. Reconstitute in sterile PBS, pH 7.4 to a concentration of 50 μg/mL. Do not vortex. This solution can be stored at 2-8℃ for up to 1 month. For extended storage, it is recommended to store at -20℃.
产品性质
biological source【生物来源】
human
recombinant【重组】
expressed in HEK 293 cells
tag【标签】
6-His tagged (N-terminus)
Assay【测定】
≥95% (SDS-PAGE)
form【形式】
lyophilized
mol wt【分子量】
calculated mol wt 17.7 kDa
observed mol wt 25-32 kDa by SDS-PAGE (reducing) (His is the predicted N-terminal .)
packaging【包装】
pkg of 10 μg
impurities【杂质】
<1 EU/μg endotoxin (LAL test)
UniProt accession no.【UniProt登记号】
P48023
shipped in【运输】
wet ice
storage temp.【储存温度】
−20℃
Gene Information
human ... FASLG(356)
安全信息
Storage Class Code【储存分类代码】
11 - Combustible Solids
WGK
WGK 3
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