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Fosaprepitant dimeglumine
产品别名
265121-04-8
Fosaprepitant dimeglumine
[3-{[(2R,3S)-2-[(1R)-1-[3,5-bis(trifluoromethyl)phenyl] ethoxy]-3-(4-fluorophenyl)morpholin-4-yl]methyl}-5-oxo- 2H-1,2,4-triazol-1-yl]phosphonic acid
1-Deoxy-1(methylamino)-D-glucitol[3-[[(2R,3S)-2-[(1R)-1-[3,5-bis(trifluoromethyl)phenyl]ethoxy]-3-(4-fluorophenyl)4-morpholinyl]methyl]-2,5-dihydro-5-oxo-1H-1,2,4-triazol-1-yl]phosphonate (2:1) (salt)
L-758,298
MK-0517
结构式
基本信息
| Empirical Formula【经验(实验)分子式】 | C23H22F7N4O6P · C14H34N2O10 |
| Molecular weight | 1004.83 |
| NACRES | NA.77 |
| Biochem/physiol Actions【生化/生理作用】 | Fosaprepitant dimeglumine acts as a therapeutic agent to treat chemotherapy-induced nausea and vomiting. It also acts as a weak inhibitor of cytochrome P450 3A4 (CYP3A4). Fosaprepitant dimeglumine is a Substance P/neurokinin-1 (NK1) receptor antagonist. It is a water soluble prodrug of the antiemetic drug aprepitant. |
产品性质
| Assay【测定】 | ≥98% (HPLC) |
| form【形式】 | powder |
| optical activity【旋光性】 | [α]/D +27 to +34°, c = 0.5 in methanol |
| storage condition【储存条件】 | desiccated |
| color【颜色】 | white to beige |
| solubility【溶解性】 | H2O: 2 mg/mL, clear |
| shipped in【运输】 | wet ice |
| storage temp.【储存温度】 | −20℃ |
| SMILES string | FC1=CC=C([C@@H]2N(CCO[C@@H]2O[C@@H](C3=CC(C(F)(F)F)=CC(C(F)(F)F)=C3)C)CC(NC4=O)=NN4P(O)(O)=O)C=C1.CNC[C@@H]([C@H]([C@@H]([C@@H](CO)O)O)O)O |
安全信息
| Storage Class Code【储存分类代码】 | 11 - Combustible Solids |
| WGK | WGK 3 |
