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Granulocyte Elastase Substrate human
基本信息
| Empirical Formula【经验(实验)分子式】 | C21H27N5O6 |
| Molecular weight | 445.47 |
| NACRES | NA.32 |
| Amino Acid Sequence | Glp-Pro-Val-pNA |
| General description【一般描述】 | Elastase, a glycoprotein, is a member of the serine proteases family. It is synthesized by human polymorphonuclear (PMN) leukocytes or by the pancreas. Human granulocyte elastase is liberated in large amounts from granulocytes in chronic inflammatory joint disorders. |
| Biochem/physiol Actions【生化/生理作用】 | Elastase is a catalytic enzyme that catalyzes the cleavage of carboxyl groups on tiny hydrophobic amino acids including glycine, alanine, and valine. Its main function is to break down elastin. Free elastase in some purulent synovial fluids plays a key role in articular cartilage breakdown. Increased elastase levels in the plasma have been seen in patients with evident rheumatoid arthritis. Elastase(s) can be assayed and differentiated using chromogenic and fluorogenic Pro-Val peptide substrates such as Glp-Pro-Val-pNA and MeOSuc-Ala-Ala-Pro-Val-4-MNA. |
产品性质
| Assay【测定】 | ≥95% (HPLC) |
| form【形式】 | lyophilized |
| composition【组成】 | Peptide Content, ≥85% |
| storage condition【储存条件】 | protect from light |
| storage temp.【储存温度】 | −20℃ |
安全信息
| Storage Class Code【储存分类代码】 | 13 - Non Combustible Solids |
| WGK | WGK 3 |
