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GSK3β,活性,人

GSK3β active human
产品编号:4119085
规格:recombinant, expressed in baculovirus infected Sf9 cells, ≥80% (SDS-PAGE)
CAS NO:443900-95-6
包装规格:10 μG
产品类别:进口试剂
品牌:Sigma-Aldrich
优惠价:立即咨询
产品价格
产品编号包装单位单价(元)国内现货国外库存询价单
411908510 μG7030
产品别名

443900-95-6

GSK3β,活性,人

GSK3β active human

glycogen synthase kinase 3 beta

基本信息
NACRES
NA.32
General description【一般描述】
Human GSK3beta GenBank Accession No. NM_002093), full length with N-terminal GST-tag, MW=73 kDa, expressed in a Baculovirus infected Sf9 cell expression system.
Glycogen Synthase Kinase 3β (GSK3β) is one of the two isoforms of GSK3 enzyme, both of which are encoded by different genes. This protein is predominantly cytoplasmic, but is also found to be localized to nucleus and mitochondria. It is a protein-serine kinase. This protein contains a protein kinase domain in its core, and is composed of 482 amino acids with a molecular weight of 46,712Da. It shows a wide range of tissue expression with the highest expression in brain.
Application【应用】
Useful for the study of enzyme kinetics, screening inhibitors, and selectivity profiling.
Biochem/physiol Actions【生化/生理作用】
Glycogen Synthase Kinase 3β (GSK3β) is responsible for rapid cyclin D1 turnover by phosphorylating it on Thr-286. It functions as a negative regulator of Wnt signaling during embryonic development and cell proliferation in adult tissues. This protein phosphorylates and regulates multiple proteins such as glycogen synthase, insulin receptor substrate-1, axin and APC (adenomatous polyposis coli). This protein is also shown to interact with multiple protein which are linked with Alzheimer′s disease (AD).
产品性质
biological source【生物来源】
human
recombinant【重组】
expressed in baculovirus infected Sf9 cells
Assay【测定】
≥80% (SDS-PAGE)
form【形式】
aqueous solution
Specific Activity
≥500 pmol/min-μg
mol wt【分子量】
73 kDa
packaging【包装】
pkg of 10 μg
technique(s)
activity assay: suitable
inhibition assay: suitable
NCBI accession no.【NCBI登记号】
NM_002093
UniProt accession no.【UniProt登记号】
P49841
shipped in【运输】
dry ice
storage temp.【储存温度】
−70℃
Gene Information
human ... GSK3B(2932)
安全信息
Storage Class Code【储存分类代码】
12 - Non Combustible Liquids
WGK
WGK 1
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