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HGK (1-328), active, GST tagged human

产品编号:4119172
规格:PRECISIO® Kinase, recombinant, expressed in baculovirus infected Sf9 cells, ≥70% (SDS-PAGE), buffered aqueous glycerol solution
包装规格:10 μG
产品类别:进口试剂
品牌:Sigma-Aldrich
优惠价:立即咨询
产品价格
产品编号包装单位单价(元)国内现货国外库存询价单
411917210 μG6580
产品别名

HGK (1-328), active, GST tagged human

FLH21957

MAP4K4

FLJ90111

FLJ20373

NIK

FLJ10410

KIAA0687

基本信息
NACRES
NA.32
General description【一般描述】
Hepatocyte progenitor kinase-like/germinal center kinase-like kinase (HGK) i or mitogen-activated protein kinase kinase kinase kinase 4(MAP4K4) is a member of the serine/threonine protein kinase family. HGK has been shown to specifically activate MAPK8/JNK. The activation of MAPK8 by HGK can be inhibited by dominant-negative mutants of MAP3K7(mitogen-activated protein kinase kinase kinase 7)/TAK1(transforming growth factor β-activated kinase 1), MAP2K4/MKK4 (mitogen-activated protein kinase kinase 4), and MAP2K7/MKK7, which suggest that this kinase functions through the MAP3K7-MAP2K4-MAP2K7 kinase cascade and mediates TNF-α signaling. HGK-dependent signaling inhibits peroxisome proliferator-activated receptor γ(PPARγ)-responsive gene expression, adipogenesis, and insulin-stimulated glucose transport. MAP4K4 gene is mapped to human chromosome 2q11.2.
Biochem/physiol Actions【生化/生理作用】
Mitogen-activated protein kinase kinase kinase kinase 4(MAP4K4) enzyme participates in promoting and suppressing inflammatory process. The MAP4K4 gene is upregulated in adenocarcinoma. Map4k4 in mice, is necessary for normal lymphatic vascular function. From endothelium-specific Map4k4 knockout models, it is found that atherosclerosis and lymphocyte recruitment might be induced by Map4k4. MAP4K4 is known to cause insulin resistance which is associated with Type 2 diabetes mellitus pathogenesis. It mediates tumor necrosis factor-α induced β cells necrosis.
Physical form【外形】
Supplied in 50mM Tris-HCl, pH 7.5, 150mM NaCl, 10mM glutathione, 0.1mM EDTA, 0.25mM DTT, 0.1mM PMSF, 25% glycerol.
Preparation Note【制备说明】
after opening, aliquot into smaller quantities and store at -70 ℃. Avoid repeating handling and multiple freeze/thaw cycles
Legal Information【法律信息】
PRECISIO is a registered trademark of sigma-aldrich Co. LLC
产品性质
recombinant【重组】
expressed in baculovirus infected Sf9 cells
product line【产品线】
PRECISIO® Kinase
Assay【测定】
≥70% (SDS-PAGE)
form【形式】
buffered aqueous glycerol solution
Specific Activity
46-62 nmol/min·mg
mol wt【分子量】
~64 kDa
NCBI accession no.【NCBI登记号】
NP_004825
shipped in【运输】
dry ice
storage temp.【储存温度】
−70℃
Gene Information
human ... MAP4K4(9448)
安全信息
Storage Class Code【储存分类代码】
10 - Combustible liquids
WGK
WGK 1
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