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Histone H3 (1-136) human
| 产品编号： | 4119187 |
| 规格： | recombinant, expressed in E. coli, ≥95% (SDS-PAGE) |
| 包装规格： | 100 μG |
| 产品类别： | 进口试剂 |
| 品牌： | Sigma-Aldrich |
| 优惠价： | 立即咨询 |
产品别名
Histone H3 (1-136) human
Histone H3/b
Histone H3/c
Histone H3/a
Histone H3/l
Histone H3/j
Histone H3/h
Histone H3/k
Histone H3/f
Histone H3/I
Histone H3/d
基本信息
| NACRES | NA.32 |
| General description【一般描述】 | The mammalian chromatin is present in nucleosomes, made of histone octamers (H2A,H2B,H3,H4)2. Mammals contain three main classes of histone H3 variants: the replicative histones (H3.1 and H3.2), the replacement histone (H3.3) and the centromeric histone (Cenp-A). |
| Biochem/physiol Actions【生化/生理作用】 | Histone proteins are basic building blocks of chromatin. Changes in the circulating H3 levels are associated with death in sepsis patients. Post-translational modifications of histone tails control chromatin organization and gene transcription. Trimethylated histone H3 lysine 4 (H3K4me3) is present at actively transcribed genes and it helps in promotion of gene expression. Histone H3K36 trimethylation (H3K36me3) is lost in various cancers and is linked with poor patient outcome. Dimethylated H3K9 (H3K9me2) is mainly present in euchromatin and is linked with repressed promoter areas. Histone methyltransferase G9a is responsible for hypoxic stress-mediated H3K9me2 in mammalian cells. |
| Physical form【外形】 | Lyophilized powder. Recommended buffer is 50 mM sodium phosphate, pH 7.2, containing 100 mM sodium chloride and 20% glycerol. |
产品性质
| biological source【生物来源】 | human |
| recombinant【重组】 | expressed in E. coli |
| Assay【测定】 | ≥95% (SDS-PAGE) |
| form【形式】 | lyophilized powder |
| mol wt【分子量】 | 15.5 kDa (1-136 aa) |
| packaging【包装】 | pkg of 100 and 250 μg |
| UniProt accession no.【UniProt登记号】 | P68431 |
| shipped in【运输】 | dry ice |
| storage temp.【储存温度】 | −70℃ |
| Gene Information | human ... HIST1H3A(8350) |
安全信息
| Storage Class Code【储存分类代码】 | 13 - Non Combustible Solids |
| WGK | WGK 3 |
