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JNJ0966
产品别名
315705-75-0
JNJ0966
N-[2-[(2-Methoxyphenyl)amino]-4′-methyl[4,5′-bithiazol]-2′-yl]acetamide
结构式
基本信息
| Empirical Formula【经验(实验)分子式】 | C16H16N4O2S2 |
| Molecular weight | 360.45 |
| MDL number | MFCD02045222 |
| Biochem/physiol Actions【生化/生理作用】 | JNJ0966 is a potent and highly selective inhibitor of matrix metalloproteinase-9 (MMP-9) zymogen activation. It appears that JNJ0966 binds to a structural pocket in proximity to the MMP-9 zymogen cleavage site near Arg-106. JNJ0966 reduces disease severity in in a mouse experimental autoimmune encephalomyelitis (EAE) model. JNJ0966 does not inhibit activation of MMP-2 zymogen, and has no effect on MMP-1, MMP-2, MMP-3, MMP-9 or MMP-14 catalytic activity. |
产品性质
| Assay【测定】 | ≥98% (HPLC) |
| form【形式】 | powder |
| color【颜色】 | white to beige |
| solubility【溶解性】 | DMSO: 2 mg/mL, clear |
| storage temp.【储存温度】 | 2-8℃ |
安全信息
| Storage Class Code【储存分类代码】 | 11 - Combustible Solids |
| WGK | WGK 3 |
