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JTE-607
产品别名
188791-09-5
JTE-607
(-)-Ethyl-N-{3,5-dichloro-2-hydroxy-4-[2-(4-methylpiperazin-1-yl)ethoxy]benzoyl}-L-phenylalaninate dihydrochloride
JTE 607
N-[3,5-Dichloro-2-hydroxy-4-[2-(4-methyl-1-piperazinyl)ethoxy]benzoyl]-L-phenylalanine ethyl ester dihydrochloride
结构式
基本信息
| Empirical Formula【经验(实验)分子式】 | C25H31Cl2N3O5·2HCl |
| Molecular weight | 597.36 |
| MDL number | MFCD07363998 |
| Biochem/physiol Actions【生化/生理作用】 | JTE-607 is a pro-drug, which carboxylic form (JTE-607-COOH) is a potent cytokine release inhibitor. JTE-607 reduces the production of proinflammatory cytokines in models of acute injury, septic shock and endotoxemia. It also inhibits proliferation of AML cell in vitro and in xenograft model. JTE-607 is an inhibitor of CPSF3 (pre-messenger RNA endonuclease cleavage and polyadenylation specificity factor 3) that directly binds to CPSF3 and blocks the release of newly synthesized pre-mRNAs. |
产品性质
| Quality Level【质量水平】 | 100 |
| Assay【测定】 | ≥98% (HPLC) |
| form【形式】 | powder |
| color【颜色】 | white to beige |
| solubility【溶解性】 | H2O: 2 mg/mL, clear |
| storage temp.【储存温度】 | 2-8℃ |
安全信息
| Storage Class Code【储存分类代码】 | 11 - Combustible Solids |
| WGK | WGK 3 |
