LKB1(STK11) Protein

expressed in baculovirus infected Sf9 cells

70-95% (SDS-PAGE)

frozen liquid

~85 kDa

0.2 μg/μL

NM_000455

dry ice

−70℃

human ... LKB1(6794)

Useful for Western blot and in kinases assays as a downstream substrate for SRC or MEK1 kinases.

Recombinant full-length human LKB1(STK11) was expressed by Baculovirus in Sf9 insect cells using an N-terminal GST tag. LKB1(STK11) is a member of the serine/threonine kinase family which regulates cell polarity and functions as a tumor suppressor. STK11 is a critical barrier to pulmonary tumorigenesis which controlling initiation, differentiation, and metastasis. STK11 plays a central role in restricting HSC entry into cell cycle and in broadly maintaining energy homeostasis in hematopoietic cells through a novel metabolic checkpoint ⁽¹⁾. STK11 serves as an essential regulator of HSCs and hematopoiesis, and more generally, points to the critical importance of coupling energy metabolism and stem cell homeostasis ⁽²⁾.

Formulated in 50mM Tris-HCl, pH 7.5, 150mM NaCl, 10mM glutathione, 0.25 mM DTT, 0.1 mM PMSF, with 25% glycerol.

Store in aliquots at -70℃. Avoid freeze/thaw cycles.

10 - Combustible liquids

WGK 1