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Lobaplatin
产品别名
135558-11-1
Lobaplatin
[rel-(1R,2R)-1,2-cyclobutanedimethanamine-κN,kN′][(2S)-2-(hydroxy-kO)propanoato(2-)-kO]-, (SP-4-3)-platinum
Cis-[trans-1,2-cyclobutanebis(methylamine)-N,N′]-[(2S)-lactate-O1,O2)-platinum (II)
D19466
trans-1,2-Cyclobutanedimethanamine, platinum complex
D 19466
D-19466
基本信息
| Empirical Formula【经验(实验)分子式】 | C9H18N2O3Pt |
| Molecular weight | 397.33 |
| Biochem/physiol Actions【生化/生理作用】 | Lobaplatin (D-19466) is a third-generation platinum anticancer agent in vitro and in vivo, consisting of ~50:50 mixture of the two trans-1,2-cyclobutanedimethanamine diastereomers in complex with L-lactic acid. Llobaplatin shows antitumor efficacy against various human cancer cancer xenografts and significantly prolongs the survival of mice bearing P388 leukemia (mean life span increase post single i.p. in mg/kg = 46%/4.64 & 77/14.7). Compared to first and second generation platinum compounds, lobaplatin appears to be more stable, less toxic, have a better therapeutic index and may overcome tumor resistance. |
产品性质
| Quality Level【质量水平】 | 100 |
| Assay【测定】 | ≥98% (NMR) |
| form【形式】 | powder |
| color【颜色】 | white to beige |
| solubility【溶解性】 | H2O: 2 mg/mL, clear (Warmed) |
| storage temp.【储存温度】 | −20℃ |
