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MEKK1 (900-1748)，有源，GST 标记 人
MEKK1 (900-1748), active, GST tagged human
| 产品编号： | 4120099 |
| 规格： | PRECISIO® Kinase, recombinant, expressed in baculovirus infected Sf9 cells, ≥70% (SDS-PAGE), buffered aqueous glycerol solution |
| 包装规格： | 10 μG |
| 产品类别： | 进口试剂 |
| 品牌： | Sigma-Aldrich |
| 优惠价： | 立即咨询 |
产品别名
MEKK1 (900-1748)，有源，GST 标记 人
MEKK1 (900-1748), active, GST tagged human
MEKK
MAP3K1
MAPKKK1
基本信息
| NACRES | NA.32 |
| General description【一般描述】 | MEKK1 or MEK kinase, is a serine/threonine kinase that is downstream of mitogenic and metabolic stimuli, including insulin and many growth factors. MEKK1 functions not only as an upstream activator of ERK and JNK through its kinase domain, but also as an E3 ligase through its PHD domain, providing a negative regulatory mechanism for decreasing ERK1/ERK2 activity by ubiquitination and degradation. MEKK1 -/- embryonic stem cells from mice show loss or altered responses of JNK to microtubule disruption and cold stress. Furthermore, activation of JNK is lost and that of ERK is diminished in response to hyperosmolarity and serum factors in MEKK1 -/- cells. |
| Physical form【外形】 | Supplied in 50mM Tris-HCl, pH 7.5, 150mM NaCl, 10mM glutathione, 0.1mM EDTA, 0.25mM DTT, 0.1mM PMSF, 25% glycerol. |
| Preparation Note【制备说明】 | after opening, aliquot into smaller quantities and store at -70 ℃. Avoid repeating handling and multiple freeze/thaw cycles |
| Legal Information【法律信息】 | PRECISIO is a registered trademark of sigma-aldrich Co. LLC |
产品性质
| recombinant【重组】 | expressed in baculovirus infected Sf9 cells |
| product line【产品线】 | PRECISIO® Kinase |
| Assay【测定】 | ≥70% (SDS-PAGE) |
| form【形式】 | buffered aqueous glycerol solution |
| Specific Activity | 697-943 nmol/min·mg |
| mol wt【分子量】 | ~155 kDa |
| NCBI accession no.【NCBI登记号】 | NM_005921 |
| shipped in【运输】 | dry ice |
| storage temp.【储存温度】 | −70℃ |
| Gene Information | human ... MAP3K1(4214) |
安全信息
| Storage Class Code【储存分类代码】 | 10 - Combustible liquids |
| WGK | WGK 1 |
