您的位置：首页 > 产品中心 > PC4, F77P mutant human
PC4, F77P mutant human
| 产品编号： | 4139553 |
| 规格： | recombinant, expressed in E. coli, ≥80% (SDS-PAGE) |
| 包装规格： | 10 μG |
| 产品类别： | 进口试剂 |
| 品牌： | Sigma-Aldrich |
| 优惠价： | 立即咨询 |
产品别名
PC4, F77P mutant human
MGC102747
P15
p14
PC4
产品性质
| biological source【生物来源】 | human |
| recombinant【重组】 | expressed in E. coli |
| Assay【测定】 | ≥80% (SDS-PAGE) |
| form【形式】 | frozen liquid |
| mol wt【分子量】 | ~14.4 kDa |
| packaging【包装】 | pkg of 10 μg |
| concentration【浓度】 | 1000 μg/mL |
| color【颜色】 | clear colorless |
| NCBI accession no.【NCBI登记号】 | NM_006713 |
| UniProt accession no.【UniProt登记号】 | P53999 |
| shipped in【运输】 | dry ice |
| storage temp.【储存温度】 | −70℃ |
| Gene Information | human ... SUB1(10923) |
基本信息
| Biochem/physiol Actions【生化/生理作用】 | Human PC4 is a non-TAF transcription coactivator that mediates activator-dependent transcription by RNA polymerase II in vitro through most tested activators. The function of PC4 is through interactions with transcriptional activators and the basal transcription machinery. It is negatively regulated by casein kinase II phosphorylation both in vitro and in vivo. PC4 strongly binds single stranded DNA and the region essential for the single stranded DNA binding activity was mapped around residue 77. A single amino acid change at position 77 (F to P) abolishes both ds- and ss-DNA binding activity. |
| Physical form【外形】 | Clear and colorless frozen liquid solution |
| Preparation Note【制备说明】 | Use a manual defrost freezer and avoid repeated freeze-thaw cycles. While working, please keep sample on ice. |
安全信息
| Storage Class Code【储存分类代码】 | 10 - Combustible liquids |
| WGK | WGK 1 |
