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PF-06843195
| 产品编号： | 4139656 |
| 规格： | ≥98% (HPLC), storage temp.: 2-8°C |
| CAS NO： | 2067281-51-8 |
| 产品类别： | 进口试剂 |
| 品牌： | Sigma-Aldrich |
| 优惠价： | 立即咨询 |
产品价格
| 产品编号 | 包装单位 | 单价(元) | 国内现货 | 国外库存 | 询价单 |
| 4139656 | ≥98% (HPLC), storage temp.: 2-8°C | 836 | |||
| 4139656 | ≥98% (HPLC), storage temp.: 2-8°C | 3230 |
产品别名
2067281-51-8
PF-06843195
PF-06862309 active drug
PF 06862309 active drug
2,2-Difluoroethyl (3S)-3-[[2′-amino-5-fluoro-2-(4-morpholinyl)[4,5′-bipyrimidin]-6-yl]amino]-3-(hydroxymethyl)-1-pyrrolidinecarboxylate
PF 06843195
PF06843195
基本信息
| Empirical Formula【经验(实验)分子式】 | C20H25F3N8O4 |
| Molecular weight | 498.46 |
| Biochem/physiol Actions【生化/生理作用】 | Potent and PI3K-alpha subtype-selective phosphoinositide 3-kinase (PI3K) inhibitor. PF-06843195 is a potent and PI3K-alpha subtype-selective phosphoinositide 3-kinase (PI3K) inhibitor (rat PI3K Ki = 2 nM/β, <18 nM/α, <280 nM/δ) that inhibits cellular PI3Kα activity at a higher potency over that of PI3Kδ/β and mTOR (AKT pT308 IC50 = 18/160/360 nM in rat PI3Kα/δ/β Rat1 lines; p70S6K pT389 IC50 = 1.5 μM in Rat1 myristoylated PI3K line). PF-06843195 is more potent against cellular AKT pT308 (MCF7/T47D IC50 = 7.8/8.7 nM) and proliferation (MCF7/T47D = 62/32 nM) than alpelisib (BYL719) in cultures. |
产品性质
| Quality Level【质量水平】 | 100 |
| Assay【测定】 | ≥98% (HPLC) |
| form【形式】 | powder |
| color【颜色】 | white to beige |
| solubility【溶解性】 | DMSO: 2 mg/mL, clear |
| storage temp.【储存温度】 | 2-8℃ |
安全信息
| Storage Class Code【储存分类代码】 | 11 - Combustible Solids |
| WGK | WGK 3 |
