您的位置：首页 > 产品中心 > PKN3 active, GST tagged human
PKN3 active, GST tagged human
| 产品编号： | 4139771 |
| 规格： | PRECISIO® Kinase, recombinant, expressed in baculovirus infected Sf9 cells, ≥70% (SDS-PAGE), buffered aqueous glycerol solution |
| 包装规格： | 10 μG |
| 产品类别： | 进口试剂 |
| 品牌： | Sigma-Aldrich |
| 优惠价： | 立即咨询 |
产品别名
PKN3 active, GST tagged human
RP11-545E17.1
基本信息
| NACRES | NA.32 |
| General description【一般描述】 | PKN3 or PRK3 is a serine/threonine protein kinase which can associate with RHOA in a GTP-dependent manner. PKN3 can also interact with GRAF and GRAF2 via the SH3 domains and phosphorylate these proteins. PKN3 is a mediator of malignant growth of human prostate cancer cells and functions downstream of activated PI3K. PKN3 is upregulated in human tumor cells but not in surrounding nontumorigenic tissues. Inducible knockdown of PKN3 expression inhibited metastasis in a mouse prostate tumor model. |
| Physical form【外形】 | Supplied in 50mM Tris-HCl, pH 7.5, 150mM NaCl, 10mM glutathione, 0.1mM EDTA, 0.25mM DTT, 0.1mM PMSF, 25% glycerol. |
| Preparation Note【制备说明】 | after opening, aliquot into smaller quantities and store at -70 ℃. Avoid repeating handling and multiple freeze/thaw cycles |
| Legal Information【法律信息】 | PRECISIO is a registered trademark of sigma-aldrich Co. LLC |
产品性质
| recombinant【重组】 | expressed in baculovirus infected Sf9 cells |
| product line【产品线】 | PRECISIO® Kinase |
| Assay【测定】 | ≥70% (SDS-PAGE) |
| form【形式】 | buffered aqueous glycerol solution |
| Specific Activity | 2.5-3.5 nmol/min·mg |
| mol wt【分子量】 | ~130 kDa |
| NCBI accession no.【NCBI登记号】 | NM_013355 |
| shipped in【运输】 | dry ice |
| storage temp.【储存温度】 | −70℃ |
| Gene Information | human ... PKN3(29941) |
安全信息
| Storage Class Code【储存分类代码】 | 10 - Combustible liquids |
| WGK | WGK 1 |
