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ppTG21 trifluoroacetate salt
产品别名
ppTG21 trifluoroacetate salt
GLFHALLHLLHSLWHLLLHA-OH TFA salt
Gly-Leu-Phe-His-Ala-Leu-Leu-His-Leu-Leu-His-Ser-Leu-Trp-His-Leu-Leu-Leu-His-Ala TFA salt
基本信息
| Empirical Formula【经验(实验)分子式】 | C115H173N31O22 · xC2HF3O2 |
| Molecular weight | 2341.80 (free base basis) |
| Biochem/physiol Actions【生化/生理作用】 | ppTG21 is an endosomolytic agent (pI 7.7, charge +1.3 @ pH 7.4) that facilitates cell type-specific gene editing by enabling endosome escape of Cas9 ribonucleoprotein (RNP) complex following its uptake via receptor-mediated endocytosis. Following liver-specific asialoglycoprotein receptor (ASGPr)-mediated delivery of ASGPr ligand (ASGPrL)-harboring & SV40 nuclear localization sequence (NLS)-bearing S. pyogenes Cas9 (Cas9-2lig-1NLS) RNP with EMX1-targeting sgRNA, target gene editing occurs only upon coincubation of the RNP in the presence of 30 molar equiv of ppTG21 (ave 4.8% indels in HepG2 cells vs. 0.2% indels without ppTG21). |
产品性质
| Quality Level【质量水平】 | 100 |
| Assay【测定】 | ≥95% (HPLC) |
| form【形式】 | film or powder |
| color【颜色】 | white to beige |
| storage temp.【储存温度】 | −20℃ |
安全信息
| Storage Class Code【储存分类代码】 | 11 - Combustible Solids |
| WGK | WGK 3 |
