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RAR γ-ligand binding domain (150-417) human
产品编号: | 4140238 |
规格: | recombinant, expressed in E. coli, ≥80% (SDS-PAGE) |
包装规格: | 10 μG |
产品类别: | 进口试剂 |
品牌: | Sigma-Aldrich |
优惠价: | 立即咨询 |
产品别名
RAR γ-ligand binding domain (150-417) human
RARC
NR1B3
基本信息
NACRES | NA.26 |
Biochem/physiol Actions【生化/生理作用】 | Retinoic acid receptors are important in the regulation of growth and differentiation of epithelial tissues, embryonic and central nervous system development and hematopoiesis. Retinoids mediate their effect by two classes of nuclear receptor proteins, the retinoic acid receptors (RARs) and the retinoid X receptors (RXRs), that each consist of three isotypes ( α, β, and γ) encoded in separate genes. Upon dimerization with RXR, RARs can bind to specific enhancer sequences in the DNA, so-called retinoic acid response elements (RAREs), resulting in transcriptional activation of target genes in the presence of ligand. The RAR-gamma in the adult is found almost exclusively in the skin. Retinoids affect epidermal cell growth and differentiation as well as sebaceous gland activity and exhibit immunomodulatory and anti-inflammatory properties. Current retinoid research targets the development of receptor-selective retinoids for tailoring and/or improving their therapeutic profile. |
Physical form【外形】 | Clear and colorless frozen liquid solution |
Preparation Note【制备说明】 | Use a manual defrost freezer and avoid repeated freeze-thaw cycles. While working, please keep sample on ice. |
产品性质
biological source【生物来源】 | human |
recombinant【重组】 | expressed in E. coli |
Assay【测定】 | ≥80% (SDS-PAGE) |
form【形式】 | frozen liquid |
mol wt【分子量】 | ~29.5 kDa |
packaging【包装】 | pkg of 10 μg |
storage condition【储存条件】 | avoid repeated freeze/thaw cycles |
concentration【浓度】 | 700 μg/mL |
color【颜色】 | clear colorless |
NCBI accession no.【NCBI登记号】 | NM_000966 |
UniProt accession no.【UniProt登记号】 | P13631 |
shipped in【运输】 | dry ice |
storage temp.【储存温度】 | −70℃ |
Gene Information | human ... RARG(5916) |
安全信息
Storage Class Code【储存分类代码】 | 10 - Combustible liquids |
WGK | WGK 1 |