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RBP4 human
| 产品编号： | 4140254 |
| 规格： | recombinant, expressed in HEK 293 cells, ≥90% (SDS-PAGE) |
| 包装规格： | 10 μG，50 μG |
| 产品类别： | 进口试剂 |
| 品牌： | Sigma-Aldrich |
| 优惠价： | 立即咨询 |
产品别名
RBP4 human
Retinol Binding Protein 4
RBP
PRBP
Plasma retinol-binding protein
基本信息
| NACRES | NA.32 |
| General description【一般描述】 | Retinol binding protein 4 (RBP4) is a 21kDa secreted protein encoded by the gene mapped to human chromosome 10q23–q24. RBP4 belongs to the lipocalin family, involved in the migration of small hydrophobic molecules. RBP4 is majorly expressed in liver and adipose tissues. |
| Biochem/physiol Actions【生化/生理作用】 | Retinol binding protein 4 (RBP4) acts as a primary transporter of retinol (vitamin A) in blood. RBP4 might act as a potent biomarker for abdominal obesity. Aberration in the expression of RBP4 is associated with the pathogenesis of Type 2 diabetes mellitus (T2DM), obesity and insulin resistance. Overexpression of serum RBP4 increases the risk for carotid artery plaque formation and coronary heart disease (CHD) in Chinese population. Therefore, regulation of serum RBP4 level might be implicated in prevention, diagnosis, and CHD treatment. A recent study in non-obese subjects revealed that decreased expression of glucose transporter 4 (GLUT4) in adipose tissues results in an elevated serum RBP4 level and insulin resistance. |
| Physical form【外形】 | 0.5 mg/mL of 0.2 μm-filtered solution in PBS, pH 7.2. |
产品性质
| biological source【生物来源】 | human |
| recombinant【重组】 | expressed in HEK 293 cells |
| Assay【测定】 | ≥90% (SDS-PAGE) |
| form【形式】 | liquid |
| mol wt【分子量】 | monomer ~230 kDa (Human RBP4 aa 19-201 is fused at the N-terminus to a FLAG |
| packaging【包装】 | pkg of 10 μg pkg of 50 μg |
| impurities【杂质】 | <0.1 EU/μg endotoxin (LAL test) |
| UniProt accession no.【UniProt登记号】 | P02753 |
| shipped in【运输】 | wet ice |
| storage temp.【储存温度】 | −20℃ |
| Gene Information | human ... RBP4(5950) |
安全信息
| Storage Class Code【储存分类代码】 | 13 - Non Combustible Solids |
| WGK | WGK 3 |
