STK9 Protein

expressed in baculovirus infected Sf9 cells

70-95% (SDS-PAGE)

frozen liquid

~84 kDa

0.1 μg/μL

NM_003159

dry ice

−70℃

human ... STK9(6792)

Useful for Western blot.

Recombinant human STK9 (CDKL5) (1-498) was expressed by Baculovirus in Sf9 insect cells using an N-terminal GST tag. STK9 or CDKL5 is a member of Ser/Thr protein kinase family which has protein kinase activity and is associated with X-linked infantile spasm syndrome (ISSX), also known as X-linked West syndrome, and Rett syndrome (RTT). STK9 can control nuclear speckle morphology by regulating the phosphorylation state of splicing regulatory proteins, and may be involved indirectly in pre-mRNA processing, by controlling splicing factor dynamics ⁽¹⁾. The mutations in the STK9 is a major cause of infantile spasms and early epileptic seizures in female patients, and of a later intractable seizure disorder ⁽²⁾.

Formulated in 50mM Tris-HCl, pH 7.5, 50mM NaCl, 10mM glutathione, 0.25 mM DTT, 0.1 mM PMSF, with 25% glycerol.

Store in aliquots at -70℃. Avoid freeze/thaw cycles.

10 - Combustible liquids

WGK 1