Tim-1 (human): FC (human)

human

expressed in CHO cells

≥98% (SDS-PAGE)

lyophilized

monomer 57 kDa by calculation

pkg of 100 μg

avoid repeated freeze/thaw cycles

<0.06 EU/μg endotoxin, tested

white

Q96D42

wet ice

−20℃

human ... HAVCR1(26762)

The TIM (T cell/transmembrane, immunoglobulin and mucin) family plays a critical role in regulating immune responses, including allergy, asthma, transplant tolerance, autoimmunity and the response to viral infections. The unique structure of TIM immunoglobulin variable region domains allows highly specific recognition of phosphatidylserine (PtdSer), exposed on the surface of apoptotic cells. TIM-1 (T cell-immunoglobulinmucin; also KIM-1 and HAVcr-1) is a 100 kDa, type I transmembrane glycoprotein member of the TIM family of immunoglobulin superfamily molecules. There are two cytoplasmic alternate splice forms of TIM1. One is a long (359 aa) kidney form termed TIM-1b, and one is a short (334 aa) liver form termed TIM-1a. TIM-1, important for asthma and allergy, is preferentially expressed on T-helper 2 (Th2) cells and functions as a potent costimulatory molecule for T cell activation.

Lyophilized from 0.2 μm-filtered solution in PBS.

Reconstitute at 100 μg/mL in sterile PBS.

The extracellular domain of human Tim-1 (aa 21-295) is fused to the N-terminus of the Fc region of human IgG1.

12 - Non Combustible Liquids

WGK 2