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Tivozanib
产品别名
475108-18-0
Tivozanib
1-[2-Chloro-4-(6,7-dimethoxyquinolin-4-yl)oxyphenyl]-3-(5-methyl-1,2-oxazol-3-yl)urea
KRN951
N-[2-Chloro-4-[(6,7-dimethoxy-4-quinolinyl)oxy]phenyl]-N?-(5-methyl-3-isoxazolyl)urea
AV-951
结构式
基本信息
| Empirical Formula【经验(实验)分子式】 | C22H19ClN4O5 |
| Molecular weight | 454.86 |
| MDL number | MFCD15146788 |
| Biochem/physiol Actions【生化/生理作用】 | Tivozanib (KRN951) is an oral, next-generation vascular endothelial growth factor receptor (VEGFR) tyrosine kinase inhibitor (TKI). Tivozanib is a potent, selective inhibitor of VEGFRs 1, 2, and 3 with a long half-life designed to improve efficacy and tolerability. |
产品性质
| Quality Level【质量水平】 | 100 |
| Assay【测定】 | ≥98% (HPLC) |
| form【形式】 | powder |
| color【颜色】 | white to beige |
| solubility【溶解性】 | DMSO: 2 mg/mL, clear |
| storage temp.【储存温度】 | 2-8℃ |
| SMILES string | O=C(NC1=C(Cl)C=C(C=C1)OC2=C3C=C(C(OC)=CC3=NC=C2)OC)NC4=NOC(C)=C4 |
安全信息
| Pictograms【象形图】 | GHS07 |
| Signal word【警示用语：】 | Warning |
| Hazard Statements | H302 |
| Precautionary Statements | P264 - P270 - P301 + P312 - P501 |
| Hazard Classifications【危险分类】 | Acute Tox. 4 Oral |
| Storage Class Code【储存分类代码】 | 11 - Combustible Solids |
| WGK | WGK 3 |
