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TR, α1, GST tagged human
产品编号: | 4141085 |
规格: | recombinant, expressed in E. coli, ≥70% (SDS-PAGE) |
包装规格: | 10 μG |
产品类别: | 进口试剂 |
品牌: | Sigma-Aldrich |
优惠价: | 立即咨询 |
产品别名
TR, α1, GST tagged human
NR1A1
ERB-T-1
AR7
ERBA1
MGC000261
THRA1
c-erbA-1
EAR7
ERBA
MGC43240
基本信息
NACRES | NA.26 |
Biochem/physiol Actions【生化/生理作用】 | Nuclear receptors form the largest known family of transcription factors and have a crucial role in nearly all aspects of vertebrate development and adult physiology by transducing the effects of hormones into transcriptional responses. The family is defined by two domains: (a) the central, highly conserved, DNA-binding domain (DBD) of approx. 66 amino acids, and (b) the C-terminal, structurally conserved, ligand-binding domain (LBD) of approximately 250 amino acids. The amino-terminal regions are least conserved among nuclear receptor sequences. This domain is highly divergent between the TR and TR isoforms, which suggests differential roles in transcriptional regulation. In addition, alternative splicing of the TR gene generates two isoforms, TR 1 and TR 2 with completely different amino-terminal domains. Unliganded TR inhibits the formation of a functional pre-initiation complex through direct interaction with TBP and transcription factor IIB. Additionally, in the absence of ligand, TR has been shown to repress transcription through recruitment of a corepressor complex, which also includes Sin3A and histone deacetylase. Ligand binding releases the corepressor complex and recruits a coactivator complex that includes multiple histone acetyltransferases, including a steroid receptor family coactivator, p300/CREB-binding protein-associated factor (PCAF), and CREB binding protein (CBP). |
Physical form【外形】 | Clear and colorless frozen liquid solution |
Preparation Note【制备说明】 | Use a manual defrost freezer and avoid repeated freeze-thaw cycles. While working, please keep sample on ice. |
产品性质
biological source【生物来源】 | human |
recombinant【重组】 | expressed in E. coli |
Assay【测定】 | ≥70% (SDS-PAGE) |
form【形式】 | frozen liquid |
mol wt【分子量】 | ~81.5 kDa |
packaging【包装】 | pkg of 10 μg |
storage condition【储存条件】 | avoid repeated freeze/thaw cycles |
concentration【浓度】 | 350 μg/mL |
color【颜色】 | clear colorless |
NCBI accession no.【NCBI登记号】 | NM_003250 |
UniProt accession no.【UniProt登记号】 | P10827 |
shipped in【运输】 | dry ice |
storage temp.【储存温度】 | −70℃ |
Gene Information | human ... THRA(7067) |
安全信息
Storage Class Code【储存分类代码】 | 10 - Combustible liquids |
WGK | WGK 1 |