TYK2 (JTK1), active, GST tagged human

NA.32

TYK2 is a member of the tyrosine kinase and, more specifically, the Janus kinases (JAKs) protein families which associates with the cytoplasmic domain of type I and type II cytokine receptors and promulgate cytokine signals by phosphorylating receptor subunits. It is also component of both the type I and type III interferon signaling pathways. TYK2 play a role in anti-viral immunity and TYK2 plays an indispensable role in controlling responses to multiple cytokines in humans. Tyk2 contributes selectively to signals triggered by various biologic stimuli and cytokine receptors and TYK2 is an important regulator of lymphoid tumor surveillance.

Supplied in 50 mM Tris-HCl, pH 7.5, 150 mM NaCl, 10 mM glutathione, 0.1 mM EDTA, 0.25 mM DTT, 0.1 mM PMSF, 25% glycerol.

After opening, aliquot into smaller quantities and store at -70 ℃. Avoid repeating handling and multiple freeze/thaw cycles.

PRECISIO is a registered trademark of sigma-aldrich Co. LLC

expressed in baculovirus infected Sf9 cells

PRECISIO^®

≥70% (SDS-PAGE)

buffered aqueous glycerol solution

19.2-28.8 nmol/min·mg

~110 kDa

NM_003331

dry ice

−70℃

human ... TYK2(7297)

10 - Combustible liquids

WGK 1