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VU0469650 hydrochloride
产品别名
VU0469650 hydrochloride
VU-0469650 HCl
3-[(3R)-3-Methyl-4-(tricyclo[3.3.1.13,7]dec-1-ylcarbonyl)-1-piperazinyl]-2-pyridinecarbonitrile, hydrochloride salt
VU 0469650 HCl
结构式
基本信息
| Empirical Formula【经验(实验)分子式】 | C22H28N4O · HCl |
| Molecular weight | 400.94 |
| Biochem/physiol Actions【生化/生理作用】 | VU0469650 is a brain-penetrant, potent and selective metabotropic glutamate receptor 1 (mGlu1) negative allosteric modulator (NAM). VU0469650 selectively inhibits glu-induced Ca2+ influx in human mGluR1-expressing HEK 293A (EC50 = 99 nM with [Glu] = EC20 for 1.9 min, then EC100 for 1.7 min; inactive against cells expressing human mGlu2-8 at 10 μM) with no affinity toward a panel of 68 clinically relevant GPCRs, ion channels, kinases, and transporters. Prior administration of VU0469650 in mice in vivo (60 mg/kg i.p.) modulates the antipsychotic activity of M4 muscarinic receptor PAM VU0467154 and that of the M1/M4 agonist xanomeline. |
产品性质
| Quality Level【质量水平】 | 100 |
| Assay【测定】 | ≥98% (HPLC) |
| form【形式】 | powder |
| optical activity【旋光性】 | [α]/D -41 to -51°, c = 1 in methanol |
| color【颜色】 | white to beige |
| solubility【溶解性】 | DMSO: 2 mg/mL, clear (warmed) |
| storage temp.【储存温度】 | 2-8℃ |
安全信息
| Storage Class Code【储存分类代码】 | 11 - Combustible Solids |
| WGK | WGK 3 |
