Imiquimod-CAS 99011-02-6-Calbiochem

C₁₄H₁₆N₄

240.30

MFCD00866946

An imidazoquinoline compound that acts as a potent immunomodulator and displays anti-angiogenic, anti-viral and anti-inflammatory properties. Reported to bind to the cell surface receptor, TLR7 (toll-like receptor 7), and induce the secretion of several pro-inflammatory cytokines and chemokines both in vitro and in vivo.

Primary Target
TLR7 (toll-like receptor 7)
Product does not compete with ATP.
Reversible: no
Cell permeable: no

Toxicity: Toxic (F)

warming to 60°C is required for complete solubilization.

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C. Upon thawing, warming may be required to resolubilize precipitated product.

Majewski, S., et al. 2005. Int. J. Dermatol.44, 14.
Gibson, S.J., et al. 2002. Cell. Immunol.218, 74.
Hemmi, H., et al. 2002. Nat. Immunol.3, 196.
Megyeri, K., et al. 1995. Mol. Cell. Biol.15, 2207.
Due to the nature of the Hazardous Materials in this shipment, additional shipping charges may be applied to your order. Certain sizes may be exempt from the additional hazardous materials shipping charges. Please contact your local sales office for more information regarding these charges.

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

100

≥98% (HPLC)

solid

Calbiochem^®

OK to freeze
protect from light

white

DMSO: 3 mg/mL

ambient

2-8℃

1S/C14H16N4/c1-9(2)7-18-8-16-12-13(18)10-5-3-4-6-11(10)17-14(12)15/h3-6,8-9H,7H2,1-2H3,(H2,15,17)

DOUYETYNHWVLEO-UHFFFAOYSA-N

250 mg in Plastic ampoule
Packaged under inert gas

GHS06

Danger

H301 - H315 - H319

P264 - P270 - P280 - P301 + P310 - P302 + P352 - P305 + P351 + P338

Acute Tox. 3 Oral - Eye Irrit. 2 - Skin Irrit. 2

6.1A - Combustible, acute toxic Cat. 1 and 2 / very toxic hazardous materials

WGK 3