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2-(3-(Piperidin-4-yl)phenyl)ethan-1-amine dihydrochloride
产品别名
2-(3-(Piperidin-4-yl)phenyl)ethan-1-amine dihydrochloride
Semi-flexible linker for PROTAC development
结构式
基本信息
| Empirical Formula【经验(实验)分子式】 | C13H22Cl2N2 |
| Molecular weight | 277.23 |
| Application【应用】 | 2-(3-(Piperidin-4-yl)phenyl)ethan-1-amine dihydrochloride is a 4-aryl piperidine useful as a semi-flexible linker in PROTAC development for targeted protein degradation. Incorporation of rigidity into the linker region of bifunctional protein degraders may impact the 3D orientation of the degrader and thus ternary complex formation as well as optimization of drug-like properties. |
| Other Notes【其他说明】 | Crosslinkers for Bioconjugation Technology Spotlight: Degrader Building Blocks for Targeted Protein Degradation Portal: Building PROTAC® Degraders for Targeted Protein Degradation |
| Legal Information【法律信息】 | PROTAC is a registered trademark of Arvinas Operations, Inc., and is used under license |
产品性质
| Quality Level【质量水平】 | 100 |
| Assay【测定】 | 95% |
| form【形式】 | powder |
| storage temp.【储存温度】 | 2-8℃ |
| SMILES string | NCCC1=CC=CC(C2CCNCC2)=C1.Cl.Cl NCCC1=CC=CC(C2CCNCC2)=C1.Cl.Cl |
安全信息
| Storage Class Code【储存分类代码】 | 11 - Combustible Solids |
| WGK | WGK 3 |
