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2-Chloro-1-(6-methoxy-1,2,3,4-tetrahydroquinolin-1-yl)ethan-1-one
产品别名
57368-84-0
2-Chloro-1-(6-methoxy-1,2,3,4-tetrahydroquinolin-1-yl)ethan-1-one
Electrophilic scout fragment
Scout fragment for targetable cysteine
KB02
2-Chloro-1-(6-methoxy-3,4-dihydroquinolin-1(2H)-yl)ethan-1-one
1-(Chloroacetyl)-1,2,3,4-tetrahydro-6-quinolinyl methyl ether
结构式
基本信息
| Empirical Formula【经验(实验)分子式】 | C12H14ClNO2 |
| Molecular weight | 239.70 |
| MDL number | MFCD09376367 |
| Application【应用】 | 2-Chloro-1-(6-methoxy-1,2,3,4-tetrahydroquinolin-1-yl)ethan-1-one is a cysteine-reactive small-molecule fragment for chemoproteomic and ligandability studies for both traditionally druggable proteins as well as "undruggable," or difficult-to-target, proteins. This fragment electrophile, or "scout" fragment, can be used alone in fragment-based covalent ligand discovery or incorporated into bifunctional tools such as electrophilic PROTAC® molecules for targeted protein degradation as demonstrated by the Cravatt Lab Lab for E3 ligase discovery. |
| Other Notes【其他说明】 | Technology Spotlight: Proteomic Ligandability Assessment The Proteome-Wide Potential for Reversible Covalency at Cysteine Electrophilic PROTACs that degrade nuclear proteins by engaging DCAF16 Proteome-wide covalent ligand discovery in native biological systems |
| Legal Information【法律信息】 | PROTAC is a registered trademark of Arvinas Operations, Inc., and is used under license |
产品性质
| Quality Level【质量水平】 | 100 |
| Assay【测定】 | ≥95% |
| form【形式】 | chunks |
| storage temp.【储存温度】 | 2-8℃ |
安全信息
| Storage Class Code【储存分类代码】 | 11 - Combustible Solids |
| WGK | WGK 3 |
