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2-Methylnicotinic acid imidazolide
产品别名
1055970-47-2
2-Methylnicotinic acid imidazolide
1H-Imidazol-1-yl(2-methyl-3-pyridinyl)methanone
(1H-imidazol-1-yl)(2-methylpyridin-3-yl)methanone
RNA structure probe
mNAI
NAI
3-(1H-imidazole-1-carbonyl)-2-methylpyridine
RNA SHAPE probe
结构式
基本信息
| Empirical Formula【经验(实验)分子式】 | C10H9N3O |
| Molecular weight | 187.20 |
| MDL number | MFCD25954959 |
| Application【应用】 | 2-Methylnicotinic acid imidazolide (NAI or mNAI) is an RNA SHAPE probe for live-cell RNA structure profiling. SHAPE -- or selective 2′-hydroxyl acylation analyzed by primer extension -- uses small, electrophilic chemical probes to react with the 2′-hydroxyl group and provides insight to RNA structure and its dynamics in varied cells states or in cells with gene knockouts. It has also been extended to the SHALiPE approach, selective 2′-hydroxyl acylation with lithium ion-based primer extension. |
| Other Notes【其他说明】 | Conditional control of RNA-guided nucleic acid cleavage and gene editing Guidelines for SHAPE Reagent Choice and Detection Strategy for RNA Structure Probing Studies SnapShot: RNA Structure Probing Technologies Structural Analysis using SHALiPE to Reveal RNA G-Quadruplex Formation in Human Precursor MicroRNA Determination of in vivo RNA structure in low-abundance transcripts |
产品性质
| form【形式】 | powder |
| Quality Level【质量水平】 | 100 |
| mp | 68-72 ℃ |
| storage temp.【储存温度】 | 2-8℃ |
安全信息
| Storage Class Code【储存分类代码】 | 11 - Combustible Solids |
| WGK | WGK 3 |
