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β-Secretase Inhibitor III-Calbiochem
| 产品编号： | 4144124 |
| 规格： | The β-Secretase Inhibitor III controls the biological activity of β-Secretase. This small molecule/inhibitor is primarily used for Neuroscience applications. |
| 包装规格： | 500 μG |
| 产品类别： | 进口试剂 |
| 品牌： | Sigma-Aldrich |
| 优惠价： | 立即咨询 |
产品别名
β-Secretase Inhibitor III-Calbiochem
Inhibitor GL189, H-EVNstatineVAEF-NH2
基本信息
| Empirical Formula【经验(实验)分子式】 | C44H70N10O14 |
| Molecular weight | 963.09 |
| General description【一般描述】 | A substrate analog inhibitor of β-secretase (BACE) that completely blocks proteolytic activity in solubilized membrane fractions of BACE-transfected MDCK cells at a concentration of 5 µM. A substrate analog inhibitor of β-secretase (BACE) that completely blocks the proteolytic activity (at 5 µM) in solubilized membrane fractions from BACE transfected MDCK cells. |
| Biochem/physiol Actions【生化/生理作用】 | Product does not compete with ATP. Primary Target BACE Reversible: no Effective concentration: 5 µM completely blocking the proteolytic activity of β-secretase (BACE) in solubilized membrane fractions from BACE transfected MDCK cells Cell permeable: no |
| Warning【警告】 | Toxicity: Standard Handling (A) |
| Sequence【序列】 | H-Glu-Val-Asn-Statine-Val-Ala-Glu-Phe-NH₂ |
| Physical form【外形】 | Supplied as a trifluoroacetate salt. |
| Reconstitution【重悬】 | Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C. |
| Other Notes【其他说明】 | Capell, A., et al. 2002. J. Biol. Chem.277, 5637. Tung, J.S., et al. 2002. J. Med. Chem.45, 259. |
| Legal Information【法律信息】 | CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany |
产品性质
| Quality Level【质量水平】 | 100 |
| Assay【测定】 | ≥95% (HPLC) |
| form【形式】 | lyophilized |
| manufacturer/tradename | Calbiochem® |
| storage condition【储存条件】 | OK to freeze desiccated (hygroscopic) |
| solubility【溶解性】 | DMSO: 1 mg/mL |
| shipped in【运输】 | ambient |
| storage temp.【储存温度】 | −20℃ |
| packaging【包装】 | 500 μg in Plastic ampoule Packaged under inert gas |
安全信息
| Storage Class Code【储存分类代码】 | 11 - Combustible Solids |
| WGK | WGK 1 |
