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BocA1V1PF2
产品别名
BocA1V1PF2
(S)-2-((S)-1-((S)-2-((S)-2-((tert-Butoxycarbonyl)amino)propanamido)-3,3-dimethylbutanoyl)pyrrolidine-2-carboxamido)-3-(4-fluorophenyl)propanoic acid
IAP E3 ligase lead for protein degrader research
AVP ligand
SNIPER building block
结构式
基本信息
| Empirical Formula【经验(实验)分子式】 | C28H41FN4O7 |
| Molecular weight | 564.65 |
| Application【应用】 | BocA1V1PF2 is an in silico-derived inhibitor of apoptosis protein (IAP)-recruiting ligand for targeted protein degradation and SNIPER (specific and non-genetic IAP-dependent protein erasers) development, launched in partnership with ComInnex. Learn more about the novel IAP ligands generated through virtual screening of AVP mimetics in our Technology Spotlight. A C-terminal variant of BocA1V1PF2 is also available as A1V1PF2-OEt (917710). BocA1V1PF2 conjugates are also available for degrader synthesis. Browse our full synthesis offering here for streamlining SNIPER and PROTAC® degrader libraries: Degrader Building Blocks 916927 BocA1V1PF2-OC6-NH2 hydrochloride 917184 BocA1V1PF2-OC10-NH2 hydrochloride 917435 BocA1V1PF2-OPEG1-NH2 hydrochloride 917680 BocA1V1PF2-OPEG3-NH2 hydrochloride Technology Spotlight: Degrader Building Blocks with Inhibitor of Apoptosis Protein (IAP) In Silico-Derived Ligands |
| Other Notes【其他说明】 | In Vivo Knockdown of Pathogenic Proteins via Specific and Nongenetic Inhibitor of Apoptosis Protein (IAP)-dependent Protein Erasers (SNIPERs) SNIPERs−Hijacking IAP activity to induce protein degradation E3 Ligase Ligands for PROTACs: How They Were Found and How to Discover New Ones |
| Legal Information【法律信息】 | PROTAC is a registered trademark of Arvinas Operations, Inc., and is used under license |
产品性质
| Quality Level【质量水平】 | 100 |
| Assay【测定】 | ≥95% |
| form【形式】 | powder |
| storage temp.【储存温度】 | 2-8℃ |
| SMILES string | C[C@H](NC(OC(C)(C)C)=O)C(N[C@H](C(N1CCC[C@H]1C(N[C@H](C(O)=O)CC2=CC=C(C=C2)F)=O)=O)C(C)(C)C)=O C[C@H](NC(OC(C)(C)C)=O)C(N[C@H](C(N1CCC[C@H]1C(N[C@H](C(O)=O)CC2=CC=C(C=C2)F)=O)=O)C(C)(C)C)=O |
安全信息
| Storage Class Code【储存分类代码】 | 11 - Combustible Solids |
| WGK | WGK 3 |
