Dynamin Inhibitor II, MiTMAB-CAS 1119-97-7-Calbiochem

C₁₇H₃₈BrN

336.39

MFCD00011770

A cell-permeable cationic surfactant that reversibly inhibits dynamin GTPase activity (IC₅₀ = 3.15 µM) by targeting the PH domain and interfering with phospholipid binding. Shown to block dynamin I-dependent SVE (synaptic vesicle endocytosis) in rat brain synaptosomes and dynamin II-dependent RME (receptor-mediated endocytosis) in non-neuronal HeLa, A431, and COS-7 cells. Inhibition is competitive with respect to PS and noncompetitive with respect to GTP.

Toxicity: Corrosive (L)

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.

Quan, A., et al. 2007. Mol. Pharmacol.72, 1425.
Hill, T.A., et al. 2004. Bioorg. Med. Chem. Lett.14, 3275.
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CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

100

≥99% (titration)

solid

Calbiochem^®

OK to freeze
desiccated (hygroscopic)

white

DMSO: 10 mg/mL
water: 100 mg/mL

ambient

2-8℃

1S/C17H38N.BrH/c1-5-6-7-8-9-10-11-12-13-14-15-16-17-18(2,3)4;/h5-17H2,1-4H3;1H/q+1;/p-1

CXRFDZFCGOPDTD-UHFFFAOYSA-M

500 mg in Glass bottle
Packaged under inert gas

GHS05,GHS07,GHS08,GHS09

Danger

H302 - H315 - H318 - H335 - H373 - H400

P273 - P280 - P301 + P312 - P302 + P352 - P305 + P351 + P338 - P314

Acute Tox. 4 Oral - Aquatic Acute 1 - Eye Dam. 1 - Skin Irrit. 2 - STOT RE 2 Oral - STOT SE 3

Gastrointestinal tract, Respiratory system

11 - Combustible Solids

WGK 3