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Ellagic Acid, Dihydrate-CAS 476-66-4-Calbiochem
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产品编号 | 包装单位 | 单价(元) | 国内现货 | 国外库存 | 询价单 |
4144587 | 500 MG | 1500 |
产品别名
476-66-4
Ellagic Acid, Dihydrate-CAS 476-66-4-Calbiochem
4,4',5,5',6,6'-Hexahydroxydiphenic Acid 2,6,2',6'-Dilactone, TBBD, PRMT Inhibitor II
基本信息
Empirical Formula【经验(实验)分子式】 | C14H6O8 · 2H2O |
Molecular weight | 338.22 |
MDL number | MFCD00006914 |
General description【一般描述】 | A cell-permeable, reversible, and potent antioxidant that has anti-mutagenic and anti-carcinogenic properties. Acts as a selective and ATP-competitive inhibitor of CK2 (IC50 = 40 nM). Moderately inhibits DNA topoisomerases I and II, Lyn, PKA catalytic subunit, Lyk, GSK-3, PKC, and FGR (IC50 = 1.8, 2.1, 2.9, 3.5, 4.3, 7.5, 8.0, and 9.4 µM, respectively). Only minimally inhibits DYRK1a, CSK, RET, Flt3, and NPM-ALK (IC50 >40 µM). Shown to act as an uncompetitive inhibitor of arginine methyltransferase CARM1 and block histone H3R17 methylation. A cell-permeable, reversible, potent antioxidant that has anti-mutagenic and anti-carcinogenic properties. Acts as a selective and ATP-competitive inhibitor of CK2 (IC50 = 40 nM). Moderately inhibits DNA topoisomerases I and II, Lyn, PKA catalytic subunit, Lyk, GSK-3, PKC, and FGR (IC50 = 1.8, 2.1, 2.9, 3.5, 4.3, 7.5, 8.0, and 9.4 µM, respectively). Only minimally inhibits DYRK1a, CSK, RET, Flt3, and NPM-ALK (IC50 >40 µM). Shown to act as an uncompetitive inhibitor of arginine methyltransferase CARM1 and block histone H3R17 methylation. |
Biochem/physiol Actions【生化/生理作用】 | Primary Target CDK2 Target IC50: 40 nM against CK2; 1.8, 2.1, 2.9, 3.5, 4.3, 7.5, 8.0, and 9.4 µM, against DNA topoisomerases I and II, Lyn, PKA catalytic subunit, Lyk, GSK-3, PKC, and FGR, respectively Reversible: yes Cell permeable: yes Product competes with ATP. |
Warning【警告】 | Toxicity: Irritant (B) |
Preparation Note【制备说明】 | For complete solubilization in ethanol, slight heating may be required. |
Reconstitution【重悬】 | Following reconstitution, aliquot and freeze (-20°C). Ethanol stock solutions are stable for up to 1 week at -20°C. Alkaline solutions are unstable and should be prepared just prior to use. |
Other Notes【其他说明】 | Selvi, B.R., et al. 2009, J. Biol. Chem. In press. Cozza, G., et al. 2006. J. Med. Chem.49, 2363. Wang, B.H., et al. 1998. Planta Med. 64, 195. Constantinou, A., et al. 1995. Nutr. Cancer23, 121. Hickey, M.J., et al. 1995. Biochem. Soc. Trans.23, 607s. |
Legal Information【法律信息】 | CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany |
产品性质
Quality Level【质量水平】 | 100 |
Assay【测定】 | ≥98% (HPLC) |
form【形式】 | powder |
manufacturer/tradename | Calbiochem® |
storage condition【储存条件】 | OK to freeze protect from light |
color【颜色】 | slightly beige |
solubility【溶解性】 | 1 M NaOH: 10 mg/mL ethanol: 10 mg/mL |
shipped in【运输】 | ambient |
storage temp.【储存温度】 | 10-30℃ |
InChI | 1S/C14H6O8/c15-5-1-3-7-8-4(14(20)22-11(7)9(5)17)2-6(16)10(18)12(8)21-13(3)19/h1-2,15-18H |
InChI key | AFSDNFLWKVMVRB-UHFFFAOYSA-N |
packaging【包装】 | 500 mg in Glass bottle Packaged under inert gas |
安全信息
Pictograms【象形图】 | GHS07 |
Signal word【警示用语:】 | Warning |
Hazard Statements | H302 |
Precautionary Statements | P264 - P270 - P301 + P312 - P501 |
Hazard Classifications【危险分类】 | Acute Tox. 4 Oral |
Storage Class Code【储存分类代码】 | 11 - Combustible Solids |
WGK | WGK 1 |