InSolution β-Secretase Inhibitor IV-CAS 797035-11-1-Calbiochem

C₃₁H₃₈N₄O₅S

578.72

MFCD09037559

A cell-permeable isophthalamide compound containing hydroxyethylamine motif that binds to BACE-1 active site and potently blocks its proteolytic activity (IC₅₀ = 15 nM for BACE-1, human and 29 nM for sAPP_NF in HEK293-APP^NFEV cells). Displays greater selectivity over other aspartyl proteases (IC₅₀ = 0.23 µM, 7.6 µM and >50 µM for BACE-2, cathepsin D, and renin, respectively). The solid form of this compound (Cat. No. 565788) is also available.

Cell permeable: yes
Primary Target
β-Secretase
Target IC₅₀: 15 nM for BACE-1, human and 29 nM for sAPP_NF in HEK293-APP^NFEV cells
Reversible: yes

Toxicity: Irritant (B)

A 10 mM (500 µg/86.4 µL) solution of β-Secretase Inhibitor IV (Cat. No. 565788) in DMSO.

Following initial thaw, aliquot and freeze (-70°C). Aliquots are stable for up to 6 months at -70°C. For short term storage, aliquots are stable for up to 3 months at -20°C.

Stachel, S.J., et al. 2004. J. Med. Chem.47, 6447.

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

100

≥95% (HPLC)

liquid

Calbiochem^®

OK to freeze
avoid repeated freeze/thaw cycles
desiccated (hygroscopic)
protect from light

dry ice

−70℃

O=C(C1=CC(C(N[C@@H](CC2=CC=CC=C2)[C@H](O)CNC3CC3)=O)=CC(N(S(C)(=O)=O)C)=C1)N[C@H](C)C4=CC=CC=C4

500 μg in Glass bottle
Packaged under inert gas

10 - Combustible liquids

WGK 1

188.6 °F - (refers to pure substance)

87 ℃ - (refers to pure substance)