InSolution GSK-3 Inhibitor IX-CAS 667463-62-9-Calbiochem

C₁₆H₁₀BrN₃O₂

356.17

MFCD08705318

A cell-permeable, highly potent, selective, reversible, and ATP-competitive inhibitor of GSK-3α/β (IC₅₀ = 5 nM). Specificity was confirmed using various Cdk′s (IC₅₀ = 83 nM for Cdk5/p25, 300 nM for Cdk2/cyclin A, 320 nM for Cdk1/cyclin B, and 10 µM for Cdk4/cyclin D1), MAP kinases, PKA, PKC isoforms, PKG, CK, and IRTK (IC₅₀ ≥ 10 µM). Inhibition of GSK by BIO has been shown to result in the activation of the Wnt signaling pathway and sustained pluripotency of human and murine embryonic stem cells (ESCs).

Cell permeable: yes
Reversible: no
Product competes with ATP.
Target IC₅₀: 5 nM against GSK-3α/β

Toxicity: Carcinogenic / Teratogenic (D)

A 10 mM (500 µg/140 µl) solution of GSK-3 Inhibitor IX (Cat. No. 361550) in DMSO.

Polychronopoulos, P., et al. 2004. J. Med. Chem.47, 935.
Sato, N., et al. 2004. Nat. Med.10, 55.
Meijer, L., et al. 2003. Chem. Biol.10, 1255.

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

100

≥97% (HPLC)

liquid

Calbiochem^®

OK to freeze
desiccated (hygroscopic)
protect from light

wet ice

2-8℃

500 μg in Plastic ampoule
Packaged under inert gas

10 - Combustible liquids

WGK 2