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InSolution Staurosporine, Streptomyces sp.
| 产品编号： | 4145203 |
| 规格： | InSolution |
| CAS NO： | 62996-74-1 |
| 包装规格： | 100 μG |
| 产品类别： | 进口试剂 |
| 品牌： | Sigma-Aldrich |
| 优惠价： | 立即咨询 |
产品价格查看更多规格...
| 产品编号 | 包装单位 | 单价(元) | 国内现货 | 国外库存 | 询价单 |
| 4145203 | 100 μG | 2570 |
产品别名
62996-74-1
InSolution Staurosporine, Streptomyces sp.
PKA Inhibitor II, MLCK Inhibitor I
基本信息
| Empirical Formula【经验(实验)分子式】 | C28H26N4O3 |
| Molecular weight | 466.53 |
| MDL number | MFCD00077402 |
| General description【一般描述】 | A potent, cell-permeable broad spectrum inhibitor of protein kinases. Inhibits CaM kinase (IC50 = 20 nM), myosin light chain kinase (IC50 = 1.3 nM), protein kinase A (IC50 = 7 nM), protein kinase C (IC50 = 0.7 nM), and protein kinase G (IC50 = 8.5 nM). Also inhibits platelet aggregation induced by collagen or ADP but has no effect on thrombin-induced platelet aggregation. Induces apoptosis in human malignant glioma cell lines. Arrests normal cells at the G1 checkpoint. |
| Biochem/physiol Actions【生化/生理作用】 | Cell permeable: yes Product competes with ATP. Target IC50: 7 nM, 20 nM, 1.3 nM, 700 pM, 8.5 nM, against protein kinase A , CaM kinase, myosin light chain kinase, protein kinase C, and protein kinase G, respectively Reversible: yes Primary Target PKA |
| Warning【警告】 | Toxicity: Irritant (B) |
| Physical form【外形】 | A 1 mM (100 µg/214 µl) solution of Staurosporine (Cat. No. 569397) in DMSO. |
| Reconstitution【重悬】 | Following initial thaw, aliquot, purge with inert gas, and freeze (-70°C). |
| Other Notes【其他说明】 | Couldwell, W.T., et al. 1994. FEBS Lett.345, 43. Nishimura, H. and Simpson, I.A. 1994. Biochem. J.302, 271. Bruno, S., et al. 1992. Cancer Res.52, 470. Kiss, Z. and Deli, E. 1992. Biochem. J.288, 853. Vitale, M.L., et al. 1992. Neuroscience51, 463. Hoffman, R. and Newland, E.S. 1991. Cancer Chemotherap. Pharmacol.28, 102. Oka, S., et al. 1986. Agric. Biol. Chem.50, 2723. |
| Legal Information【法律信息】 | CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany |
产品性质
| Quality Level【质量水平】 | 100 |
| Assay【测定】 | ≥97% (HPLC) |
| form【形式】 | liquid |
| manufacturer/tradename | Calbiochem® |
| storage condition【储存条件】 | OK to freeze protect from light |
| shipped in【运输】 | wet ice |
| storage temp.【储存温度】 | −70℃ |
| InChI | 1S/C28H26N4O3/c1-28-26(34-3)17(29-2)12-20(35-28)31-18-10-6-4-8-14(18)22-23-16(13-30-27(23)33)21-15-9-5-7-11-19(15)32(28)25(21)24(22)31/h4-11,17,20,26,29H,12-13H2,1-3H3,(H,30,33)/t17-,20-,26-,28+/m1/s1 |
| InChI key | HKSZLNNOFSGOKW-FYTWVXJKSA-N |
| packaging【包装】 | 100 μg in Plastic ampoule Packaged under inert gas |
安全信息
| Storage Class Code【储存分类代码】 | 10 - Combustible liquids |
| WGK | WGK 1 |
| Flash Point(F)【闪点(F)】 | 188.6 °F - (Dimethylsulfoxide) |
| Flash Point(C)【闪点(C)】 | 87 ℃ - (Dimethylsulfoxide) |
