NEMO-Binding Domain Binding Peptide, Cell-Permeable, Negative Control-Calbiochem

C₁₅₄H₂₄₉N₄₇O₄₂S

3462.98

A cell-permeable, Antennapedia-NBD mutated (Trp⁷³⁹ → Ala and Trp⁷⁴¹ → Ala) fusion peptide analog of NEMO-Binding Domain Binding peptide (Cat. No. 480025) that serves as a negative control. Reported to be defective in binding to NEMO. Does not affect the TNF-α-induced phosphorylation of c-Jun or DNA binding of the transcription factor Oct-1.
A cell-permeable Antennapedia-NBD mutated (Trp⁷³⁹ and Trp⁷⁴¹ replaced with Ala) fusion peptide analog of NEMO-Binding Domain Binding Peptide (Cat. No. 480025) that serves as a negative control. Shown to be defective in binding to NEMO. Does not affect the TNF-α-induced phosphorylation of c-Jun and DNA binding of the transcription factor Oct-1.

Cell permeable: yes
Primary Target
Negative control defective in binding to NEMO
Product does not compete with ATP.
Reversible: no

Toxicity: Standard Handling (A)

H₂N-Asp-Arg-Gln-Ile-Lys-Ile-Trp-Phe-Gln-Asn-Arg-Arg-Met-Lys-Trp-Lys-Lys-Thr-Ala-Leu-Asp-Ala-Ser-Ala-Leu-Gln-Thr-Glu-OH

This peptide will precipitate when added to tissue culture medium even at 100 µM concentrations; however, sufficient material will stay in solution to permeate cells.
Jimi, E., et al. 2004. Nat. Med., 10, 617.
May, M.J., et al. 2000. Science289, 1550.

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

100

≥95% (HPLC)

lyophilized solid

Calbiochem^®

OK to freeze
desiccated (hygroscopic)

off-white

DMSO: 50 mg/mL

ambient

−20℃

500 μg in Plastic ampoule
Packaged under inert gas

11 - Combustible Solids

WGK 1