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Poly(ethylene glycol) α-hydroxy-ω-azido terminated
产品别名
Poly(ethylene glycol) α-hydroxy-ω-azido terminated
α-Hydroxy-ω-azido-PEG
PEG-Azide
结构式
基本信息
| Linear Formula【线性分子式】 | N3CH2CH2(OCH2CH2)nOH |
| NACRES | NA.23 |
| General description【一般描述】 | α-Hydroxy-ω-azido terminated-poly(ethylene glycol) is a heterobifunctional PEG derivative that can be used to modify peptides, proteins, or other bioconjugation chemistry applications. PEGylated materials have found broad use in drug delivery systems, virology, and immunology, as the incorporation of PEG improves pharmacological properties such as increased water solubility, enhanced resistance to degradation (protein hydrolysis), increased circulation half-life, and reduced antigenicity. In addition to PEGylation, this heterobifunctional PEG can also be used to form networks for tissue engineering or drug delivery applications due to its dual reactivity. |
| Application【应用】 | α-Hydroxy-ω-azido terminated-poly(ethylene glycol) features two distinct, terminal functional groups: an azide and a hydroxyl group. The terminal azide can undergo copper(I)-catalyzed azide-alkyne cycloaddition (CuAAC) or strain promoted azide-alkyne cycloaddition (spAAC), depending on reaction conditions and the identity of the alkyne. In addition, the terminal azide can be reduced to an amine in mild conditions for use in other coupling reactions. The free hydroxyl allows for additional functionalization or a secondary coupling reaction. |
产品性质
| Quality Level【质量水平】 | 100 |
| form【形式】 | powder or chunks |
| mol wt【分子量】 | Mn 1500-2500 (by NMR) average Mn 2,000 |
| color【颜色】 | white to off-white |
| storage temp.【储存温度】 | −20℃ |
安全信息
| Storage Class Code【储存分类代码】 | 13 - Non Combustible Solids |
| WGK | WGK 3 |
