钌红-CAS 11103-72-3-Calbiochem

[(NH₃)₅RuORu(NH₃)₄ORu(NH₃)₅]Cl₆

NA.77

A blocker of transmembrane Ca²⁺ fluxes (IC₅₀ = 7 µM) that attenuates capsaicin-induced cation channel opening. Inhibits Ca²⁺-induced Ca²⁺ release from ryanodine-sensitive intracellular Ca²⁺ stores. Inhibits K⁺-stimulated catecholamine secretion (IC₅₀ = 6 µM).
Ruthenium: ≥35%

Primary Target
Blocker of transmembrane Ca2+ fluxes
Target IC₅₀: 7 µM in blocking transmembrane Ca2+ fluxes; 6 µM inhibiting K+-stimulated catecholamine secretion
Product does not compete with ATP.
Reversible: no
Cell permeable: no

Toxicity: Harmful (C)

Merck Index 13, 8379.
Phillippe, M. and Basa, A. 1996. Biochem. Biophys. Res. Commun. 221, 656.
Buratti, R., et al. 1995. Biochem. Biophys. Res. Commun. 213, 1082.
Hamilton, M.G. and Lundy, P.M. 1995. J. Pharmacol. Exp. Ther. 273, 940.
Gomis, A., et al. 1994. Biochem. Pharmacol. 47, 225.
Stjame, P., et al. 1994. Acta Otolaryngol. 114, 651.
Ma, J. 1993. J. Gen. Physiol.102, 1031.

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

100

solid

Calbiochem^®

OK to freeze
desiccated

red-black

ammonia: soluble
water: soluble

ambient

10-30℃

250 mg in Glass bottle

GHS07

Warning

H302

P264 - P270 - P301 + P312 - P501

Acute Tox. 4 Oral

11 - Combustible Solids

WGK 2