Anti-Werner′s syndrome helicase (WRN) Antibody, clone 20A11.1

32160702

NA.41

The Werner’s syndrome helicase (RecQ-like type 3; RecQ3; Exonuclease WRN) is a ubiquitously expressed nuclear protein belonging to the RecQ family. It functions as a helicase and exonuclease enzyme, and plays a crucial role in the formation of DNA replication centers. This protein is also involved in DNA repair and recombination, and may be involved in transcriptional events mediated by RNA polymerase II. It is regulated by phosphorylation and is targeted by the DNA-dependent protein kinase enzyme. Disrupted expression of the gene encoding the Werner’s syndrome helicase protein often results in the production of truncated Werner’s syndrome helicase proteins. Over 50 gene mutations may contribute to this effect—and lead to the development of Werner syndrome, a condition characterized by accelerated aging and early onset of age-related conditions such as cancer, atherosclerosis, and osteoporosis.

GST-tagged recombinant protein corresponding to human WRN.

Use Anti-WRN Antibody, clone 20A11.1 (Mouse Monoclonal Antibody) validated in WB to detect WRN clone 20A11.1 also known as Werner syndrome ATP-dependent helicase, RecQ3, Exonuclease WRN.
Research Category
Epigenetics & Nuclear Function
Research Sub Category
Chromatin Biology

Evaluated by Western Blot in HEK293 cell lysate.

Western Blot Analysis: A 1:2,000 dilution of this antibody detected Werner′s syndrome helicase (WRN) in 10 µg of HEK293 cell lysate.

Purified mouse monoclonal IgG1κ in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.
Format: Purified
Protein G Purified

Control
HEK293 cell lysate

100

mouse

purified antibody

primary antibodies

20A11.1, monoclonal

human

western blot: suitable

IgG1κ

NP_000544

Q14191

wet ice

human ... WRN(7486)

~162 kDa observed

Stable for 1 year at 2-8°C from date of receipt.

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12 - Non Combustible Liquids

WGK 1